1997年香港甲型禽流感（H5N1）疾病危险因素的病例对照研究。

Case-control study of risk factors for avian influenza A (H5N1) disease, Hong Kong, 1997.

作者信息

Mounts A W, Kwong H, Izurieta H S, Ho Y, Au T, Lee M, Buxton Bridges C, Williams S W, Mak K H, Katz J M, Thompson W W, Cox N J, Fukuda K

机构信息

Epidemic Intelligence Service, Epidemiology Program Office, Division of Applied Public Health Training, National Center for Infectious Diseases, Centers for Disease Control, Atlanta, GA 30033

出版信息

J Infect Dis. 1999 Aug;180(2):505-8. doi: 10.1086/314903.

DOI:10.1086/314903

PMID:10395870

Abstract

In May 1997, a 3-year-old boy in Hong Kong died of a respiratory illness related to influenza A (H5N1) virus infection, the first known human case of disease from this virus. An additional 17 cases followed in November and December. A case-control study of 15 of these patients hospitalized for influenza A (H5N1) disease was conducted using controls matched by age, sex, and neighborhood to determine risk factors for disease. Exposure to live poultry (by visiting either a retail poultry stall or a market selling live poultry) in the week before illness began was significantly associated with H5N1 disease (64% of cases vs. 29% of controls, odds ratio, 4.5, P=.045). By contrast, travel, eating or preparing poultry products, recent exposure to persons with respiratory illness, including persons with known influenza A (H5N1) infection, were not associated with H5N1 disease.

摘要

1997年5月，香港一名3岁男童死于与甲型流感（H5N1）病毒感染相关的呼吸系统疾病，这是已知的首例感染该病毒的人类病例。11月和12月又出现了17例病例。对15名因甲型流感（H5N1）疾病住院的患者进行了病例对照研究，使用年龄、性别和社区匹配的对照来确定疾病的危险因素。发病前一周接触活禽（通过参观零售家禽摊位或活禽市场）与H5N1疾病显著相关（64%的病例与29%的对照，优势比为4.5，P = 0.045）。相比之下，旅行、食用或制备家禽产品、近期接触呼吸道疾病患者，包括已知感染甲型流感（H5N1）的患者，与H5N1疾病无关。