Sali A
Rockefeller University, New York, NY 10021-6399, USA.
Mol Med Today. 1995 Sep;1(6):270-7. doi: 10.1016/s1357-4310(95)91170-7.
Approximately one third of known protein sequences are related to at least one known protein structure. As a result, an order of magnitude more sequences can be modeled by comparative modeling than there are experimentally determined protein structures. A large fraction of these models has an accuracy approaching that of a low resolution X-ray structure or a medium resolution nuclear magnetic resonance structure. The number of applications where homology modeling has been proven useful is growing rapidly.
已知的蛋白质序列中约有三分之一与至少一种已知的蛋白质结构相关。因此，通过比较建模能够构建的序列数量比通过实验测定的蛋白质结构数量多一个数量级。这些模型中的很大一部分的准确性接近低分辨率X射线结构或中等分辨率核磁共振结构的准确性。已被证明有用的同源建模应用数量正在迅速增长。
