Foks H, Wisterowicz K, Damasiewicz B, Nasal A, Petrusewicz J, Radwańska A
Department of Organic Chemistry, Medical University of Gdańsk.
Acta Pol Pharm. 1997 Jan-Feb;54(1):55-62.
A series of pyrazinylamino-1,3-diazacycloalkanes was obtained by reaction of the corresponding substituted aminopyrazines with aliphatic amines. Selected compounds were studied with respect to their potential circulatory activity. The effect on the blood pressure, isolated rat tail artery and heart atria, and an influence on the human blood platelet aggregation were investigated.
通过相应的取代氨基吡嗪与脂肪胺反应，得到了一系列吡嗪基氨基-1,3-二氮杂环烷烃。对选定的化合物进行了潜在循环活性方面的研究。研究了它们对血压、离体大鼠尾动脉和心房的影响，以及对人体血小板聚集的影响。
