Kees S, Langevitz P, Zemer D, Padeh S, Pras M, Livneh A
Heller Institute of Medical Research, Sheba Medical Center, Tel-Hashomer, Israel.
QJM. 1997 Oct;90(10):643-7. doi: 10.1093/qjmed/90.10.643.
Familial Mediterranean fever (FMF) is characterized by recurrent attacks of febrile serositis. While arthritis, pleuritis and peritonitis are common in FMF, no association of pericarditis with FMF has been described in detail. We retrospectively studied about 4000 FMF patients, using a computer chart review. Pericarditis was diagnosed when patients sustained attacks of pleuritic retrosternal chest pain and had typical findings in the electrocardiogram, echocardiogram or chest radiogram. The incidence and features of pericarditis in FMF were compared to published data. Over a period of 20 years, one or more episodes of pericarditis were recorded in 27 patients, a significantly higher incidence than in the general population (68 vs. 6 per 10(5) per year, p < 0.001). Each patient experienced 1-3 pericarditis attacks, lasting a mean of 4.2 days, accompanied by high temperature and symptoms of FMF attack at another site. The pericarditis attack resolved spontaneously and left no sequelae. FMF patients with pericarditis were comparable to other FMF patients in most demographic and clinical parameters. Pericarditis may be considered another rare manifestation of FMF.
家族性地中海热（FMF）的特征为发热性浆膜炎反复发作。虽然关节炎、胸膜炎和腹膜炎在FMF中很常见，但心包炎与FMF的关联尚未得到详细描述。我们使用计算机病历回顾对约4000例FMF患者进行了回顾性研究。当患者出现胸骨后胸膜炎性胸痛发作且心电图、超声心动图或胸部X线检查有典型表现时，诊断为心包炎。将FMF中心包炎的发病率和特征与已发表的数据进行了比较。在20年的时间里，27例患者记录了一次或多次心包炎发作，发病率显著高于一般人群（每年每10⁵人中68例对6例，p < 0.001）。每位患者经历1 - 3次心包炎发作，平均持续4.2天，伴有高热及FMF在其他部位发作的症状。心包炎发作可自行缓解，无后遗症。患有心包炎的FMF患者在大多数人口统计学和临床参数方面与其他FMF患者相当。心包炎可被视为FMF的另一种罕见表现。
