Tautz C, Bögelspacher H R, Klaissle K
Onkologie. 1979 Oct;2(5):199-203. doi: 10.1159/000214611.
A double-blind pilot study of 130 female patients was carried out to determine the feasibility and significance of the EM test in the early diagnosis of carcinoma of the female genital organs and breast. Early stages of cervical carcinoma (carcinoma in situ) as well as fibroid adenoma, mastopathy and breast tumors were tested and compared with the results of their manifest forms. Positive results were recorded in 87.5% of the cases of middle-grade to severe epithelial dysplasia (Papanicolaou III and IV) (n = 10) and in 90% of the cases of carcinoma in situ (n = 16). A positive result in 90% of the cases of carcinoma in situ (n = 16). A positive result in 90% of the cases of genital carcinoma was also recorded. In the case of fibroid adenoma (n = 10) and breast tumor (Prechtel I and II) (n = 16), negative results were recorded in 80.8%, whereas in the manifest forms of carcinoma of the breast a positive result of over 95% was shown. As a result of this pilot study, it can be seen that immunological in vitro screening has clinical significance in the early diagnosis of tumors as well as for confirmation of their manifest forms.
对130名女性患者进行了一项双盲试验研究，以确定EM检测在女性生殖器官和乳腺癌症早期诊断中的可行性和意义。对宫颈癌早期阶段（原位癌）以及纤维瘤腺瘤、乳腺病和乳腺肿瘤进行了检测，并将结果与其明显症状形式的结果进行了比较。在中度至重度上皮发育异常（巴氏Ⅲ级和Ⅳ级）（n = 10）的病例中，87.5%的结果呈阳性，在原位癌（n = 16）的病例中，90%的结果呈阳性。在90%的原位癌（n = 16）病例中结果呈阳性。在90%的生殖器官癌病例中也记录到阳性结果。在纤维瘤腺瘤（n = 10）和乳腺肿瘤（普雷希特尔Ⅰ级和Ⅱ级）（n = 16）的病例中，80.8%的结果呈阴性，而在乳腺癌的明显症状形式中，超过95%的结果呈阳性。作为这项试验研究的结果，可以看出体外免疫筛查在肿瘤的早期诊断以及对其明显症状形式的确认方面具有临床意义。
