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淋巴细胞上清液与红细胞的电泳迁移率:癌症诊断的进一步经验

Lymphocyte supernatants and the electrophoretic mobility of erythrocytes: further experience of cancer diagnosis.

作者信息

Dyson J E, Watkinson A P, Jones W G, Corbett P J, Joslin C A

出版信息

Br J Cancer. 1980 Sep;42(3):448-54. doi: 10.1038/bjc.1980.257.

DOI:10.1038/bjc.1980.257
PMID:7000116
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2010423/
Abstract

A double-blind trial of the tanned-erythrocyte electrophoretic mobility test for cancer has been carried out. This included 70 normal subjects as controls, 61 subjects with disease other than cancer, and 229 cancer patients. Slowing values generally increased in the order given, with certain diseases having values within the range positive for cancer. Exposure to viral infection also tended to produce false positives. Slowing values above 50%, however, appear to be definitely associated with cancer. For the middle range of slowing values (25-50%) there is some overlap between the 3 groups, so that a statistical probability of the presence of malignancy is available from the test. With slowing values below 25% there is little likelhood of cancer. Tumour type influences the test result, as does, to a lesser extent, tumour bulk.

摘要

已对用于癌症检测的鞣酸红细胞电泳迁移率试验进行了双盲试验。该试验包括70名正常受试者作为对照组,61名患有非癌症疾病的受试者,以及229名癌症患者。减慢值通常按上述顺序增加,某些疾病的数值在癌症阳性范围内。接触病毒感染也往往会产生假阳性。然而,减慢值超过50%似乎肯定与癌症有关。对于减慢值的中间范围(25%-50%),三组之间存在一些重叠,因此该试验可得出存在恶性肿瘤的统计概率。减慢值低于25%时,患癌症的可能性很小。肿瘤类型会影响检测结果,肿瘤大小在较小程度上也会影响检测结果。

相似文献

1
Lymphocyte supernatants and the electrophoretic mobility of erythrocytes: further experience of cancer diagnosis.淋巴细胞上清液与红细胞的电泳迁移率:癌症诊断的进一步经验
Br J Cancer. 1980 Sep;42(3):448-54. doi: 10.1038/bjc.1980.257.
2
Effect of lymphocyte supernatants on the electrophoretic mobility of erythrocytes: significance in cancer diagnosis.淋巴细胞上清液对红细胞电泳迁移率的影响:在癌症诊断中的意义
Br J Cancer. 1978 Sep;38(3):401-10. doi: 10.1038/bjc.1978.221.
3
[Electrophoretic mobility test in the early diagnosis of malignant tumors; findings in the prestages of cervical and breast cancers].[电泳迁移率试验在恶性肿瘤早期诊断中的应用;宫颈癌和乳腺癌前期的研究结果]
Onkologie. 1979 Oct;2(5):199-203. doi: 10.1159/000214611.
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[Demonstration of a factor in cerebrospinal fluid with inhibitory activity for electrophoretic cell mobility in multiple sclerosis (author's transl)].[脑脊液中一种对多发性硬化症电泳细胞迁移具有抑制活性的因子的证明(作者译)]
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Comparison between the macrophage electrophoretic mobility (MEM) and the fixed tanned erythrocyte electrophoretic mobility (FTEEM) tests in the detection of cancer.巨噬细胞电泳迁移率(MEM)检测与固定鞣酸红细胞电泳迁移率(FTEEM)检测在癌症检测中的比较。
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[Electrophoretic mobility of lymphocytes in multiple myeloma and bronchial cancer].[多发性骨髓瘤和支气管癌中淋巴细胞的电泳迁移率]
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Cell electrophoresis for diagnostic purposes. I. Diagnostic value of the electrophoretic mobility test (EMT) for the detection of gynaecological malignancies.用于诊断目的的细胞电泳。I. 电泳迁移率测试(EMT)在检测妇科恶性肿瘤中的诊断价值。
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A comparison of the kinetics of the macrophage electrophoretic mobility (MEM) and the tanned sheep erythrocyte electrophoretic mobility (TEEM) tests.巨噬细胞电泳迁移率(MEM)试验与鞣酸处理绵羊红细胞电泳迁移率(TEEM)试验的动力学比较。
J Immunol Methods. 1977;14(2):123-39. doi: 10.1016/0022-1759(77)90003-5.
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[Immune diagnosis of malignant diseases. X. Value of the electrophoresis mobility test in the diagnosis of broncho-pulmonary diseases].[恶性疾病的免疫诊断。十、电泳迁移率试验在支气管肺部疾病诊断中的价值]
Onkologie. 1978 Apr;1(2):79-84. doi: 10.1159/000213921.

本文引用的文献

1
The effects of stimulated lymphocyte supernatants on the electrophoretic mobility distribution of peritoneal macrophages.刺激淋巴细胞上清液对腹腔巨噬细胞电泳迁移率分布的影响。
J Immunol. 1980 Jan;124(1):381-7.
2
Evaluation and development of the macrophage electrophoretic mobility (MEM) test for malignant disease.恶性疾病巨噬细胞电泳迁移率(MEM)检测的评估与开发。
Br J Cancer. 1973 Jan;27(1):1-9. doi: 10.1038/bjc.1973.1.
3
The macrophage electrophoretic mobility (MEM) test for malignant disease. Further clinical investigations and studies on macrophage slowing factors.恶性疾病的巨噬细胞电泳迁移率(MEM)试验。关于巨噬细胞迟缓因子的进一步临床研究
Clin Exp Immunol. 1974 Dec;18(4):543-52.
4
Macrophage-electrophoretic-mobility (M.E.M.) test for malignant disease. An independent confirmation.巨噬细胞电泳迁移率(M.E.M.)检测恶性疾病。一项独立验证。
Lancet. 1972 Sep 23;2(7778):627-9. doi: 10.1016/s0140-6736(72)93018-8.
5
Lymphocyte sensitisation: an in-vitro test for cancer?淋巴细胞致敏:一种癌症的体外检测方法?
Lancet. 1970 Dec 26;2(7687):1337-41. doi: 10.1016/s0140-6736(70)92361-5.
6
Macrophage electrophoretic mobility (MEM) with myelin basic protein.巨噬细胞电泳迁移率(MEM)与髓鞘碱性蛋白
Br J Cancer. 1976 Dec;34(6):613-8. doi: 10.1038/bjc.1976.221.
7
An assessment of the macrophage electrophoretic mobility test (MEM) in cancer diagnosis.巨噬细胞电泳迁移率试验(MEM)在癌症诊断中的评估。
J Clin Pathol. 1976 Jul;29(7):608-9. doi: 10.1136/jcp.29.7.608.
8
Effect of lymphocyte supernatants on the electrophoretic mobility of erythrocytes: significance in cancer diagnosis.淋巴细胞上清液对红细胞电泳迁移率的影响:在癌症诊断中的意义
Br J Cancer. 1978 Sep;38(3):401-10. doi: 10.1038/bjc.1978.221.
9
Failure to obtain positive MEM tests in either cell-mediated immune conditions in the guinea-pig or in human cancer.在豚鼠的细胞介导免疫条件下或人类癌症中未能获得阳性的巨噬细胞移动抑制试验结果。
Br J Cancer. 1977 Nov;36(5):545-9. doi: 10.1038/bjc.1977.229.