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用于分子序列分析的人工神经网络

Artificial neural networks for molecular sequence analysis.

作者信息

Wu C H

机构信息

Department of Epidemiology/Biomathematics, University of Texas Health Center at Tyler 75710, USA.

出版信息

Comput Chem. 1997;21(4):237-56. doi: 10.1016/s0097-8485(96)00038-1.

Abstract

Artificial neural networks provide a unique computing architecture whose potential has attracted interest from researchers across different disciplines. As a technique for computational analysis, neural network technology is very well suited for the analysis of molecular sequence data. It has been applied successfully to a variety of problems, ranging from gene identification, to protein structure prediction and sequence classification. This article provides an overview of major neural network paradigms, discusses design issues, and reviews current applications in DNA/RNA and protein sequence analysis.

摘要

人工神经网络提供了一种独特的计算架构,其潜力吸引了不同学科研究人员的关注。作为一种计算分析技术,神经网络技术非常适合分析分子序列数据。它已成功应用于从基因识别到蛋白质结构预测和序列分类等各种问题。本文概述了主要的神经网络范式,讨论了设计问题,并综述了其在DNA/RNA和蛋白质序列分析中的当前应用。

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