Börner J, Zimmermann T, Albrecht S, Roesner D
Klinik und Poliklinik für Kinderchirurgie, Universitätsklinikum Carl Gustav Carus, Technische Universität, Dresden.
Med Klin (Munich). 1997 Sep 15;92 Suppl 3:17-9. doi: 10.1007/BF03041953.
Substitution of selenium was performed in the University Clinic of Paediatric Surgery in Dresden in the time from 1994 to 1996 in 34 children aged 1 to 16 years with severe inflammatory surgical diseases as well a s widespread burns. Seven further patients have been examined within this time who have not received substitution of selenium as preliminary comparison group. All these patients fulfilled the criteria of "Systemic Inflammatory Response Syndrome" (SIRS). The following paraclinical parameters were examined: white cell count, interleukin 6, C-reactive protein, fibrinogen, malondialdehyde, activity of glutathione peroxidase in plasma and level of selenium in plasma and whole blood.
Patients with initially low level of selenium who received substitution of selenium reached normal ranges more quickly than patients without substitution. Originally partly elevated values of malondialdehyde as sign of increased peroxidation of lipids were normalized under substitution of selenium. Initially low activity of selenium level in plasma showed a clear increase under substitution of selenium as sign of increased protection of the cell membrane.
The substitution of selenium in children with SIRS is a supportive therapy.
1994年至1996年期间，德累斯顿大学儿科外科对34名年龄在1至16岁、患有严重炎性外科疾病以及大面积烧伤的儿童进行了硒替代治疗。在此期间，还检查了另外7名未接受硒替代治疗的患者作为初步对照组。所有这些患者均符合“全身炎症反应综合征”（SIRS）的标准。检查了以下辅助临床参数：白细胞计数、白细胞介素6、C反应蛋白、纤维蛋白原、丙二醛、血浆中谷胱甘肽过氧化物酶活性以及血浆和全血中的硒水平。
初始硒水平较低且接受硒替代治疗的患者比未接受替代治疗的患者更快达到正常范围。最初作为脂质过氧化增加标志的丙二醛部分升高值在硒替代治疗后恢复正常。最初血浆中硒水平较低的活性在硒替代治疗后明显升高，这表明细胞膜的保护作用增强。
对SIRS患儿进行硒替代治疗是一种支持性疗法。
