Bowen M D, Peters C J, Nichol S T
Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
Mol Phylogenet Evol. 1997 Dec;8(3):301-16. doi: 10.1006/mpev.1997.0436.
Viruses of the Arenaviridae cause hemorrhagic fevers and neurologic disease in humans. Historically, the arenaviruses have been divided into two complexes (LASV-LCMV, Tacaribe) through the use of antigenic typing. The phylogeny of the Arenaviridae as a whole has not been estimated previously due to a lack of sequence data for all members of the family. In this study, nucleocapsid protein gene sequence data were obtained for all currently known arenaviruses and used to estimate, for the first time, a phylogeny of the entire virus family. The LCMV-LASV complex arenaviruses are monophyletic and comprise three distinct lineages. The Tacaribe complex viruses also are monophyletic and occupy three distinct lineages. Comparisons of arenavirus phylogeny with rodent host phylogeny and taxonomic relationships provide several examples in which virus-host cospeciation is potentially occurring. The pathogenic arenaviruses do not appear to be monophyletic, suggesting that the pathogenic phenotype has arisen in multiple independent events during virus evolution.
沙粒病毒科的病毒可导致人类出现出血热和神经系统疾病。历史上，沙粒病毒通过抗原分型被分为两个复合体（拉沙病毒-淋巴细胞脉络丛脑膜炎病毒，塔卡里比病毒）。由于缺乏该病毒科所有成员的序列数据，此前尚未对整个沙粒病毒科的系统发育进行估计。在本研究中，获取了所有目前已知沙粒病毒的核衣壳蛋白基因序列数据，并首次用于估计整个病毒科的系统发育。拉沙病毒-淋巴细胞脉络丛脑膜炎病毒复合体沙粒病毒是单系的，包括三个不同的谱系。塔卡里比病毒复合体病毒也是单系的，占据三个不同的谱系。沙粒病毒系统发育与啮齿动物宿主系统发育及分类关系的比较提供了几个病毒-宿主共物种形成可能正在发生的例子。致病性沙粒病毒似乎不是单系的，这表明致病表型在病毒进化过程中发生了多次独立事件。
