Robinson M, Catzeflis F, Briolay J, Mouchiroud D
Laboratoire de Biométrie, Génétique et Biologie des Populations, Université Claude Bernard, Lyon 1, UMR-CNRS 5558, Villeurbanne, France.
Mol Phylogenet Evol. 1997 Dec;8(3):423-34. doi: 10.1006/mpev.1997.0424.
Phylogenetic relationships among 19 extant species of rodents, with special emphasis on rats, mice, and allied Muroidea, were studied using sequences of the nuclear protein-coding gene LCAT (lecithin:cholesterol acyltransferase), an enzyme of cholesterol metabolism. Analysis of 705 base pairs from the exonic regions of LCAT confirmed known groupings in and around Muroidea. Strong support was found for the families Sciuridae (squirrel and marmot) and Gliridae (dormice) and for suprafamilial taxa Muroidea and Caviomorpha (guinea pig and allies). Within Muroidea, the first branching leads to the fossorial mole rats Spalacinae and bamboo rats Rhizomyinae. The other Muroidea appear as a polytomy from which are issued Gerbillinae (gerbils), Murinae (rats and mice), Sigmodontinae (New World cricetids), Cricetinae (hamsters), and Arvicolinae (voles). Evidence from LCAT sequences agrees with that from a number of previous molecular and morphological studies, both concerning branching orders inside Muroidea and the bush-like radiation of rodent suprafamilial taxa (caviomorphs, sciurids, glirids, muroids), thus suggesting that this nuclear gene is an appropriate candidate for addressing questions of rodents relationships.
利用胆固醇代谢酶——核蛋白编码基因LCAT（卵磷脂：胆固醇酰基转移酶）的序列，研究了19种现存啮齿动物之间的系统发育关系，特别着重于大鼠、小鼠及相关的鼠总科动物。对来自LCAT外显子区域的705个碱基对进行分析，证实了鼠总科及其周边已知的分类群。结果有力支持了松鼠科（松鼠和旱獭）和睡鼠科（睡鼠）以及超科分类群鼠总科和豚鼠型亚目（豚鼠及相关动物）。在鼠总科内，最早分支形成掘穴性的鼹形鼠科和竹鼠科。其他鼠总科动物表现为一个多分支类群，从中分出沙鼠亚科（沙鼠）、鼠亚科（大鼠和小鼠）、稻鼠亚科（新大陆仓鼠类）、仓鼠亚科（仓鼠）和田鼠亚科（田鼠）。来自LCAT序列的证据与先前许多分子和形态学研究的证据一致，这既涉及鼠总科内部的分支顺序，也涉及啮齿动物超科分类群（豚鼠型亚目、松鼠科、睡鼠科、鼠总科）的灌木状辐射，因此表明该核基因是解决啮齿动物亲缘关系问题的合适候选基因。
