Sharma J N, Zeitlin I J, Brooks P M, Dick W C
Agents Actions. 1976 Feb;6(1-3):148-53. doi: 10.1007/BF01972199.
Plasma kininogen levels in the peripheral venous blood of untreated patients with active rheumatoid disease was found to be more than twice the levels measured in healthy normal individuals or in convalescing uncomplicated fracture patients. Treatment with oral indomethacin or aspirin lowered the kininogen levels nearly to normal. Sequential studies showed that the fall in kininogen was very rapid, occurring within 1-2 hours of ingestion of drug, and was parallelled by reduction in the clinical indices of inflammation. Control studies showed that the kininogen changes were not due to changes in plasma volume or non-specific changes in plasma protein concentration. Indomethacin treatment had no effect on plasma kininogen levels in healthy volunteers. The significance of this finding will be discussed.
研究发现，患有活动性类风湿病且未经治疗的患者外周静脉血中的血浆激肽原水平，是健康正常个体或康复期无并发症骨折患者所测水平的两倍多。口服消炎痛或阿司匹林进行治疗可使激肽原水平降至接近正常。连续研究表明，激肽原水平下降非常迅速，在服药后1 - 2小时内即可出现，同时炎症的临床指标也会降低。对照研究表明，激肽原的变化并非由于血浆量的改变或血浆蛋白浓度的非特异性变化。消炎痛治疗对健康志愿者的血浆激肽原水平没有影响。将对这一发现的意义进行讨论。
