Rothschild A M, Cordeiro R S, Castania A
Naunyn Schmiedebergs Arch Pharmacol. 1975;288(2-3):319-21. doi: 10.1007/BF00500537.
Pulmonary edema and plasma kininogen consumption caused by intravenously administered adrenaline, were inhibited in rats pretreated with acetylsalicylic acid, but not in rats pretreated with indomethacin or sodium salicylate. The possibility of a connection between this edema and mast cell-linked activation of kallikrein by adrenaline is discussed, as well as the possible role of acetylsalicylic acid acting as an acetylating inhibitor of these processes.
静脉注射肾上腺素所致的肺水肿和血浆激肽原消耗，在预先用乙酰水杨酸处理的大鼠中受到抑制，但在预先用吲哚美辛或水杨酸钠处理的大鼠中未受抑制。本文讨论了这种水肿与肾上腺素引起的与肥大细胞相关的激肽释放酶激活之间存在联系的可能性，以及乙酰水杨酸作为这些过程的乙酰化抑制剂可能发挥的作用。
