肾上腺素降低大鼠血液中的激肽原及其被抗交感神经药、肝素和阿司匹林抑制
Lowering of kininogen in rat blood by adrenaline and its inhibition by sympatholytic agents, heparin and aspirin.
作者信息
Castania A, Rothschild A M
出版信息
Br J Pharmacol. 1974 Mar;50(3):375-81. doi: 10.1111/j.1476-5381.1974.tb09612.x.
Abstract
1 (-)-Adrenaline lowered the kininogen content and transitorily elevated the fibrinolytic activity of plasma following intravenous injection into the rat. Its effect on kininogen increased when administered by intravenous infusion.2 Although less effective, (-)-noradrenaline had a similar action to adrenaline; (+/-)-isoprenaline was inactive and failed to inhibit the effect of adrenaline.3 The effect of adrenaline on kininogen could be reproduced in vitro by incubation of whole blood, but not cell-free plasma, with the catecholamine for 5 min at 37 degrees C.4 Propranolol or phenoxybenzamine, as well as heparin or acetylsalicylic acid (aspirin), blocked the reduction of rat blood kininogen by adrenaline in vivo and in vitro.
摘要
静脉注射给大鼠后，（-）-肾上腺素降低了激肽原含量，并使血浆纤溶活性短暂升高。静脉输注给药时，其对激肽原的作用增强。
（-）-去甲肾上腺素虽然效果较差，但与肾上腺素作用相似；（±）-异丙肾上腺素无活性，且不能抑制肾上腺素的作用。
肾上腺素对激肽原的作用可通过在37℃下将全血与儿茶酚胺孵育5分钟在体外重现，但无细胞血浆则不能。
普萘洛尔或酚苄明，以及肝素或乙酰水杨酸（阿司匹林），在体内和体外均能阻断肾上腺素对大鼠血液激肽原的降低作用。
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