Medalle R, Waterhouse C, Hahn T J
Am J Clin Nutr. 1976 Aug;29(8):854-8. doi: 10.1093/ajcn/29.8.854.
Four patients with gastrointestinal disorders, and one patient with chronic alcoholism presented with both hypocalcemia and hypomagnesemia. Pharmacological doses of either ergocalciferol or dihydrotachysterol did not correct the hypocalcemia except in one patient who had a minimal rise in serum calcium. Parathormone levels were high in three patients and exogenous parathormone given to the fourth subject failed to elicit a rise in serum calcium, implying impairment of the calcemic response to parathormone. Magnesium repletion simultaneously corrected the hypomagnesemia and hypocalcemia. Balance data suggested that the rise in serum calcium was in part, at least, due to increased mobilization of minerals from bone. While the mechanism remains speculative, it appears that magnesium facilitates the release of calcium from bone in the presence of adequate amounts of vitamin D and parathormone.
4例胃肠道疾病患者和1例慢性酒精中毒患者同时出现低钙血症和低镁血症。除1例血清钙略有升高的患者外，给予药理剂量的麦角钙化醇或二氢速甾醇均不能纠正低钙血症。3例患者的甲状旁腺激素水平较高，给予第4例患者外源性甲状旁腺激素未能引起血清钙升高，这意味着对甲状旁腺激素的钙反应受损。补充镁同时纠正了低镁血症和低钙血症。平衡数据表明，血清钙的升高至少部分是由于骨中矿物质动员增加。虽然机制仍属推测，但在有足够量维生素D和甲状旁腺激素存在的情况下，镁似乎促进了骨中钙的释放。
