Hirata J D, Swiersz L M, Zell B, Small R, Ettinger B
Department of Obstetrics and Gynecology, Kaiser Permanente Medical Center, Oakland, California, USA.
Fertil Steril. 1997 Dec;68(6):981-6. doi: 10.1016/s0015-0282(97)00397-x.
To evaluate possible estrogenic effects of dong quai on vaginal cells and on endometrial thickness in postmenopausal women.
Double-blind, randomized, placebo-controlled clinical trial.
Department of Obstetrics and Gynecology in a large health maintenance organization (HMO).
PATIENT(S): Seventy-one postmenopausal women (mean age [+/- SD], 52.4 +/- 6 years) who had follicle-stimulating hormone levels (third-generation assay) of > 30 mIU/mL with hot flashes.
INTERVENTION(S): Subjects were randomized to treatment with either dong quai or placebo for 24 weeks.
MAIN OUTCOME MEASURE(S): Endometrial thickness was measured by transvaginal ultrasonography; vaginal cells were evaluated for cellular maturation; menopausal symptoms were evaluated by reviewing the Kupperman index and the diary of vasomotor flushes.
RESULT(S): We observed no statistically significant differences between groups in endometrial thickness, in vaginal maturation index, in number of vasomotor flushes, or in the Kupperman index.
CONCLUSION(S): Used alone, dong quai does not produce estrogen-like responses in endometrial thickness or in vaginal maturation and was no more helpful than placebo in relieving menopausal symptoms.
评估当归对绝经后女性阴道细胞及子宫内膜厚度可能产生的雌激素样作用。
双盲、随机、安慰剂对照临床试验。
一家大型健康维护组织（HMO）的妇产科。
71名绝经后女性（平均年龄[±标准差]，52.4±6岁），其促卵泡激素水平（第三代检测法）>30 mIU/mL且伴有潮热症状。
受试者被随机分为两组，分别接受当归或安慰剂治疗，为期24周。
通过经阴道超声测量子宫内膜厚度；评估阴道细胞的细胞成熟度；通过查阅库珀曼指数和血管舒缩性潮热日记来评估绝经症状。
我们观察到，两组在子宫内膜厚度、阴道成熟指数、血管舒缩性潮热次数或库珀曼指数方面均无统计学显著差异。
单独使用时，当归不会在子宫内膜厚度或阴道成熟方面产生类似雌激素的反应，在缓解绝经症状方面也不比安慰剂更有效。
