Stacher G, Bauer P, Schulze D, Pointner H, Landgraf M
Am J Dig Dis. 1976 Jul;21(7):563-8. doi: 10.1007/BF01464764.
In 16 experiments on 4 healthy subjects, the effect of procedures which alter blood glucose, ie, infusion of 0.2 units/kg body wt/hr insulin and/or 0.66 g/kg body wt/hr glucose, on gastric acid secretion, plasma gastrin, and plasma osmolality was studied, Each subject underwent four different experimental procedures, each lasting 4 hr. All had in common one basal hour and the infusion of insulin in the second hour, but differed in the time of infusion of glucose or isotonic saline. To control for order effects, the four procedures were applied to the subjects in the form of a Latin square. Acid output was measured continuously be means of intragastric titration and a telemetering capsule; blood glucose, plasma gastrin, and plasma osmolaity were determined in 15-min intervals. An inverse relationship between blood glucose and acid output was found: Low glucose levels were associated with high rates of acid secretion, high glucose levels with low acid secretion. No noticeable changes occurred in either plasma gastrin or plasma osmolality. These results reveal a determining influence of blood glucose levels on acid secretion. On the basis of earlier work in animals it is concluded that this influence is exerted via the reciprocal activities of the hypothalamic satiety and feeding centers.
在对4名健康受试者进行的16项实验中，研究了改变血糖的操作（即按0.2单位/千克体重/小时输注胰岛素和/或按0.66克/千克体重/小时输注葡萄糖）对胃酸分泌、血浆胃泌素和血浆渗透压的影响。每位受试者都经历了四种不同的实验操作，每种操作持续4小时。所有操作都有一个共同的基础小时，且在第二个小时输注胰岛素，但葡萄糖或等渗盐水的输注时间不同。为了控制顺序效应，以拉丁方的形式将这四种操作应用于受试者。通过胃内滴定法和遥测胶囊连续测量酸输出量；每隔15分钟测定一次血糖、血浆胃泌素和血浆渗透压。发现血糖与酸输出之间呈负相关：低血糖水平与高酸分泌率相关，高血糖水平与低酸分泌相关。血浆胃泌素和血浆渗透压均未出现明显变化。这些结果揭示了血糖水平对酸分泌的决定性影响。根据早期在动物身上的研究得出结论，这种影响是通过下丘脑饱腹感和进食中枢的相互作用来实现的。
