Elder J B, Ganguli P C, Gillespie I E, Gerring E L, Gregory H
Gut. 1975 Nov;16(11):887-93. doi: 10.1136/gut.16.11.887.
Purified human urogastrone was given by intravenous infusion to 12 normal volunteer subjects and measurements made of gastric acid, pepsin and intrinsic factor secretion, and of plasma gastrin concentration. Clinical, haematological, and biochemical screening tests were made throughout the period of study. Urogastrone inhibited acid and intrinsic factor secretion whether stimulated by pentagastrin, histamine, or insulin, but had a much less marked effect on gastric pepsin output. Plasma gastrin levels did not alter significantly. Limited dose-response studies showed that 0-25 mug urogastrone kg--1 hr--1 resulted in inhibition of acid output of 80% and was not associated with clinical side-effects. No significant alteration in any of the haematological or biochemical measurements was observed in any of the subjects.
将纯化的人尿抑胃素静脉输注给12名正常志愿者受试者，并对胃酸、胃蛋白酶和内因子分泌以及血浆胃泌素浓度进行测量。在整个研究期间进行了临床、血液学和生化筛查试验。无论由五肽胃泌素、组胺还是胰岛素刺激，尿抑胃素均能抑制胃酸和内因子分泌，但对胃蛋白酶分泌的影响则小得多。血浆胃泌素水平无明显变化。有限的剂量反应研究表明，0 - 25微克尿抑胃素·千克⁻¹·小时⁻¹可使胃酸分泌抑制80%，且无临床副作用。在任何受试者中，血液学或生化测量均未观察到显著变化。
