尿抑胃素对正常受试者胃分泌及血浆胃泌素水平的影响。
Effect of urogastrone on gastric secretion and plasma gastrin levels in normal subjects.
作者信息
Elder J B, Ganguli P C, Gillespie I E, Gerring E L, Gregory H
出版信息
Gut. 1975 Nov;16(11):887-93. doi: 10.1136/gut.16.11.887.
Abstract
Purified human urogastrone was given by intravenous infusion to 12 normal volunteer subjects and measurements made of gastric acid, pepsin and intrinsic factor secretion, and of plasma gastrin concentration. Clinical, haematological, and biochemical screening tests were made throughout the period of study. Urogastrone inhibited acid and intrinsic factor secretion whether stimulated by pentagastrin, histamine, or insulin, but had a much less marked effect on gastric pepsin output. Plasma gastrin levels did not alter significantly. Limited dose-response studies showed that 0-25 mug urogastrone kg--1 hr--1 resulted in inhibition of acid output of 80% and was not associated with clinical side-effects. No significant alteration in any of the haematological or biochemical measurements was observed in any of the subjects.
摘要
将纯化的人尿抑胃素静脉输注给12名正常志愿者受试者，并对胃酸、胃蛋白酶和内因子分泌以及血浆胃泌素浓度进行测量。在整个研究期间进行了临床、血液学和生化筛查试验。无论由五肽胃泌素、组胺还是胰岛素刺激，尿抑胃素均能抑制胃酸和内因子分泌，但对胃蛋白酶分泌的影响则小得多。血浆胃泌素水平无明显变化。有限的剂量反应研究表明，0 - 25微克尿抑胃素·千克⁻¹·小时⁻¹可使胃酸分泌抑制80%，且无临床副作用。在任何受试者中，血液学或生化测量均未观察到显著变化。
相似文献
1
Effect of urogastrone on gastric secretion and plasma gastrin levels in normal subjects.尿抑胃素对正常受试者胃分泌及血浆胃泌素水平的影响。
Gut. 1975 Nov;16(11):887-93. doi: 10.1136/gut.16.11.887.
2
Effect of urogastrone on gastric secretion and serum gastrin concentration in patients with duodenal ulceration.尿抑胃素对十二指肠溃疡患者胃分泌及血清胃泌素浓度的影响。
Gut. 1982 Nov;23(11):951-6. doi: 10.1136/gut.23.11.951.
3
Effect of urogastrone in the Zollinger-Ellison syndrome.尿抑胃素在佐林格-埃利森综合征中的作用。
Lancet. 1975 Sep 6;2(7932):424-7. doi: 10.1016/s0140-6736(75)90842-9.
4
Effect of 13-NLE-motilin on gastric secretion, serum gastrin level and mucosal blood flow in dogs.13-去甲亮氨酸-胃动素对犬胃液分泌、血清胃泌素水平及黏膜血流的影响。
J Physiol. 1977 Jan;264(3):665-72. doi: 10.1113/jphysiol.1977.sp011688.
5
The effect of somatostatin on pentagastrin-stimulated gastric secretion and on plasma gastrin in man.生长抑素对人五肽胃泌素刺激的胃分泌及血浆胃泌素的影响。
Scand J Gastroenterol. 1977;12(7):833-9. doi: 10.3109/00365527709181727.
6
Comparison of vasoactive intestinal peptide (VIP) and secretin in gastric secretion and mucosal blood flow.血管活性肠肽（VIP）与促胰液素对胃液分泌及黏膜血流影响的比较
Pflugers Arch. 1976 Jan 30;361(2):175-81. doi: 10.1007/BF00583463.
7
The effects of somatostatin and metiamide on tachyphylaxis of pentagastrin stimulated gastric acid and pepsin secretion in the conscious cat.生长抑素和甲硫咪特对清醒猫中五肽胃泌素刺激的胃酸和胃蛋白酶分泌快速耐受的影响。
J Physiol. 1977 Apr;266(3):801-17. doi: 10.1113/jphysiol.1977.sp011794.
8
Effect of somatostatin on meal-induced gastric secretion in duodenal ulcer patients.生长抑素对十二指肠溃疡患者进餐诱发胃酸分泌的影响。
Am J Dig Dis. 1977 Nov;22(11):981-8. doi: 10.1007/BF01076197.
9
The effect of carbachol and pentagastrin on the gastric secretion of acid pepsin, and intrinsic factor (IF) in man.卡巴胆碱和五肽胃泌素对人体胃酸、胃蛋白酶及内因子分泌的影响。
Scand J Gastroenterol. 1975;10(1):55-8.
10
Effect of atropine on insulin-stimulated gastrin release and gastric secretion of acid, pepsin, and intrinsic factor (IF).阿托品对胰岛素刺激的胃泌素释放以及胃酸、胃蛋白酶和内因子（IF）分泌的影响。
Scand J Gastroenterol. 1974;9(7):665-9.
引用本文的文献
1
Comparison of the antisecretory and antiulcer activity of epidermal growth factor, urogastrone and transforming growth factor alpha and its derivative in rodents in vivo.表皮生长因子、尿抑胃素、转化生长因子α及其衍生物在啮齿动物体内的抗分泌和抗溃疡活性比较
Mol Cell Biochem. 2002 Jul;236(1-2):83-94. doi: 10.1023/a:1016144016908.
2
Development and validation of two solid-phase enzyme immunoassays (ELISA) for quantitation of human epidermal growth factors (hEGFs).两种用于定量检测人表皮生长因子（hEGF）的固相酶免疫测定法（ELISA）的开发与验证。
Pharm Res. 1996 Jul;13(7):1088-94. doi: 10.1023/a:1016075128086.
3
Hemodynamic effects of epidermal growth factor in conscious rats and monkeys.表皮生长因子对清醒大鼠和猴子的血流动力学影响。
Proc Natl Acad Sci U S A. 1996 May 14;93(10):4957-61. doi: 10.1073/pnas.93.10.4957.
4
Effects of epidermal growth factor on alkaline secretion and mucus formation in rat duodenum exposed to luminal acid.表皮生长因子对暴露于腔内酸的大鼠十二指肠碱性分泌和黏液形成的影响。
Gastroenterol Jpn. 1993 Aug;28(4):496-504. doi: 10.1007/BF02776947.
5
Acid suppression and gastric mucosal cell biology.酸抑制与胃黏膜细胞生物学
Dig Dis Sci. 1994 Sep;39(9):1843-52. doi: 10.1007/BF02088113.
6
Systemic treatment with recombinant human epidermal growth factor accelerates healing of sclerotherapy-induced esophageal ulcers and prevents esophageal stricture formations in pigs.重组人表皮生长因子的全身治疗可加速猪硬化剂治疗所致食管溃疡的愈合，并预防食管狭窄的形成。
Dig Dis Sci. 1994 Dec;39(12):2671-8. doi: 10.1007/BF02087708.
7
Pancreatic secretory trypsin inhibitor in human Brunner's glands.人布伦纳腺中的胰腺分泌性胰蛋白酶抑制剂。
J Gastroenterol. 1995 Feb;30(1):90-5. doi: 10.1007/BF01211381.
8
Epidermal growth factor in saliva and gastric juice: response to histamine.唾液和胃液中的表皮生长因子：对组胺的反应。
Gut. 1995 Sep;37(3):335-9. doi: 10.1136/gut.37.3.335.
9
Effect of urogastrone on gastric secretion and serum gastrin concentration in patients with duodenal ulceration.尿抑胃素对十二指肠溃疡患者胃分泌及血清胃泌素浓度的影响。
Gut. 1982 Nov;23(11):951-6. doi: 10.1136/gut.23.11.951.
10
Chemical synthesis of a gene for human epidermal growth factor urogastrone and its expression in yeast.人表皮生长因子尿抑胃素基因的化学合成及其在酵母中的表达。
Proc Natl Acad Sci U S A. 1983 Dec;80(24):7461-5. doi: 10.1073/pnas.80.24.7461.
本文引用的文献
1
Preparation and properties of purified antisecretory substance; urogastrone.纯化抗分泌物质；尿抑胃素的制备及性质
Arch Biochem. 1950 Jan;25(1):133-40.
2
The chemical nature of urogastrone.尿抑胃素的化学性质。
Arch Biochem. 1949 Nov;24(1):104-9.
3
A METHOD FOR THE ASSAY OF HUMAN GASTRIC INTRINSIC FACTOR AND FOR THE DETECTION AND TITRATION OF ANTIBODIES AGAINST INTRINSIC FACTOR.一种检测人胃内因子的方法以及检测和滴定抗内因子抗体的方法。
Lancet. 1963 Dec 28;2(7322):1350-4. doi: 10.1016/s0140-6736(63)90736-0.
4
A new method for the preparation of urogastrone.一种制备尿抑胃素的新方法。
J Physiol. 1955 Sep 28;129(3):528-46. doi: 10.1113/jphysiol.1955.sp005375.
5
Urinary gastric secretory depressants (urogastrone).尿胃分泌抑制剂（urogastrone）。
Vitam Horm. 1951;9:313-53. doi: 10.1016/s0083-6729(08)60476-8.
6
Radio-immunoassay of gastrin in human plasma.人血浆中胃泌素的放射免疫测定
J Physiol. 1972 Jan;220(2):499-510.
7
Some polypeptides influencing gastric-acid secretion.
Am J Dig Dis. 1970 Feb;15(2):139-48. doi: 10.1007/BF02235645.
8
A nephelometric pepsin method.
Clin Chim Acta. 1969 Jun;24(3):437-43. doi: 10.1016/0009-8981(69)90117-x.
Zotero 插件