用于猪门静脉对比增强磁共振血管造影的两种原型血池造影剂。
Two prototype blood-pool agents for contrast-enhanced magnetic resonance angiography of the portal vein in pigs.
作者信息
Shibata D K, Schmiedl U P, Yuan C, Nelson J A
机构信息
Department of Radiology, University of Washington Medical Center, Seattle 98195, USA.
出版信息
Acad Radiol. 1995 Aug;2(8):705-8. doi: 10.1016/s1076-6332(05)80439-8.
RATIONALE AND OBJECTIVES
Macromolecular "blood-pool" agents such as polylysine-gadopentetate dimeglumine or albumin-gadopentetate dimeglumine, which provide prolonged intravascular enhancement, were tested as magnetic resonance (MR) angiography contrast agents for the portal vein in pigs.
METHODS
Phase-contrast MR angiography of the portal veins was performed on six pigs before and after intravenous administration of polylysine-gadopentetate dimeglumine (n = 3) or albumin-gadopentetate dimeglumine (n = 3).
RESULTS
The contrast-to-noise ratio of the portal veins was improved by 74% and 52%, respectively, using polylysine-gadopentetate dimeglumine or albumin-gadopentetate dimeglumine. More branches of the intrahepatic portal veins were visualized on postcontrast images.
CONCLUSION
Blood-pool paramagnetic contrast agents improved the visualization of hepatic vasculature using phase-contrast MR angiography in our experimental model.
原理与目的
高分子“血池”造影剂，如聚赖氨酸钆喷酸葡甲胺或白蛋白钆喷酸葡甲胺，可提供长时间的血管内强化，作为猪门静脉磁共振（MR）血管造影造影剂进行了测试。
方法
对6头猪在静脉注射聚赖氨酸钆喷酸葡甲胺（n = 3）或白蛋白钆喷酸葡甲胺（n = 3）之前和之后进行门静脉的相位对比MR血管造影。
结果
使用聚赖氨酸钆喷酸葡甲胺或白蛋白钆喷酸葡甲胺时，门静脉的对比噪声比分别提高了74%和52%。在造影后图像上可见更多肝内门静脉分支。
结论
在我们的实验模型中，血池顺磁性造影剂使用相位对比MR血管造影改善了肝血管系统的可视化。
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