Osler T, Baker S P, Long W
Department of Surgery, University of Vermont, Burlington 05405, USA.
J Trauma. 1997 Dec;43(6):922-5; discussion 925-6. doi: 10.1097/00005373-199712000-00009.
The Injury Severity Score (ISS) has served as the standard summary measure of anatomic injury for more than 20 years. Nevertheless, the ISS has an idiosyncrasy that both impairs its predictive power and complicates its calculation. We present here a simple modification of the ISS called the New Injury Severity Score (NISS), which significantly outperforms the venerable but dated ISS as a predictor of mortality.
Retrospective calculation of NISS and comparison of NISS with prospectively calculated ISS.
The NISS is defined as the sum of the squares of the Abbreviated Injury Scale scores of each of a patient's three most severe Abbreviated Injury Scale injuries regardless of the body region in which they occur. NISS values were calculated for every patient in two large independent data sets: 3,136 patients treated during a 4-year period at the American College of Surgeons' Level I trauma center in Albuquerque, New Mexico, and 3,449 patients treated during a 4-year period at the American College of Surgeons' Level I trauma center at the Emanuel Hospital in Portland, Oregon. The power of NISS to predict mortality was then compared with previously calculated ISS values for the same patients in each of the two data sets.
We find that NISS is not only simple to calculate but more predictive of survival as well (Albuquerque: receiver operating characteristic (ROC) ISS = 0.869, ROC NISS = 0.896, p < 0.001; Portland: ROC ISS = 0.896, ROC NISS = 0.907,p < 0.004). Moreover, NISS provides a better fit throughout its entire range of prediction (Hosmer Lemeshow statistic for Albuquerque ISS = 29.12, NISS = 8.88; Hosmer Lemeshow statistic for Portland ISS = 83.48, NISS = 19.86).
NISS should replace ISS as the standard summary measure of human trauma.
损伤严重度评分(ISS)作为解剖损伤的标准汇总测量指标已应用超过20年。然而,ISS存在一个特性,既损害其预测能力又使计算复杂化。我们在此提出一种对ISS的简单修改,称为新损伤严重度评分(NISS),作为死亡率预测指标,它显著优于备受尊崇但已过时的ISS。
回顾性计算NISS,并将NISS与前瞻性计算的ISS进行比较。
NISS定义为患者最严重的三处简明损伤定级(AIS)损伤的AIS评分平方之和,无论损伤发生在身体哪个部位。在两个大型独立数据集里为每位患者计算NISS值:一个数据集是新墨西哥州阿尔伯克基市美国外科医师学会一级创伤中心在4年期间治疗的3136例患者,另一个数据集是俄勒冈州波特兰市伊曼纽尔医院美国外科医师学会一级创伤中心在4年期间治疗的3449例患者。然后将两个数据集中相同患者的NISS预测死亡率的能力与先前计算的ISS值进行比较。
我们发现NISS不仅计算简单,而且对生存的预测性更强(阿尔伯克基市:受试者工作特征曲线(ROC)下ISS = 0.869,ROC下NISS = 0.896,p < 0.001;波特兰市:ROC下ISS = 0.896,ROC下NISS = 0.907,p < 0.004)。此外,NISS在其整个预测范围内拟合度更好(阿尔伯克基市ISS的霍斯默 - 莱梅肖统计量 = 29.12,NISS = 8.88;波特兰市ISS的霍斯默 - 莱梅肖统计量 = 83.48,NISS = 19.86)。
NISS应取代ISS作为人类创伤的标准汇总测量指标。