Beanlands R S, Armstrong W F, Hicks R J, Nicklas J, Moore C, Hutchins G D, Wolpers H G, Schwaiger M
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, USA.
J Nucl Cardiol. 1994 Jan-Feb;1(1):3-16. doi: 10.1007/BF02940007.
With echocardiography and dynamic carbon 11-labeled acetate (C-11 acetate) positron emission tomographic imaging, C-11 acetate kinetics and a parameter that estimates mechanical ventricular efficiency (the work metabolic index) were defined in eight patients with dilated cardiomyopathy. The effect of afterload reduction with nitroprusside on these parameters was evaluated in six of these patients. Nitroprusside increased stroke work index but decreased the C-11 clearance rate. The work metabolic index determined noninvasively increased and correlated well with an invasive approach. The work metabolic index was inversely correlated with systemic vascular resistance. Nitroprusside shifted this relationship upward and to the left.
This method of estimating efficiency is feasible and may represent a unique noninvasive approach for the evaluation of cardiac performance and responses to therapy.
通过超声心动图和动态碳-11标记乙酸盐（C-11乙酸盐）正电子发射断层成像，在8例扩张型心肌病患者中定义了C-11乙酸盐动力学和一个估计心室机械效率的参数（工作代谢指数）。在其中6例患者中评估了硝普钠降低后负荷对这些参数的影响。硝普钠增加了每搏功指数，但降低了C-11清除率。通过非侵入性测定的工作代谢指数增加，且与侵入性方法相关性良好。工作代谢指数与体循环血管阻力呈负相关。硝普钠使这种关系向上和向左移动。
这种估计效率的方法是可行的，可能代表了一种用于评估心脏功能和治疗反应的独特非侵入性方法。
