自然分娩过程中产妇催乳素的阶段性分泌与宫颈扩张及第二产程子宫活动有关。
Phasic maternal prolactin secretion during spontaneous labor is associated with cervical dilatation and second-stage uterine activity.
作者信息
Fernandes P A, Szelazek J T, Reid G J, Wodzicki A M, Allardice J G, McCoshen J A
机构信息
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Manitoba, Women's Hospital, Winnipeg, Canada.
出版信息
J Soc Gynecol Investig. 1995 Jul-Aug;2(4):597-601. doi: 10.1016/1071-5576(95)00004-x.
OBJECTIVE
In this study, we attempted to determine the physiologic roles of prolactin (PRL) and hCG during labor.
METHODS
Serial blood samples were collected from 19 women (15 multiparous and four nulliparous) before, during, and after labor; assayed for PRL and hCG; and compared with cervical dilatation and uterine contraction frequency.
RESULTS
Prolactin levels decreased in association with progressive cervical dilatation during the first stage of labor and reached a nadir at full dilatation. Thereafter, PRL increased rapidly during the second stage of labor and peaked within 1 hour postpartum. Uterine contraction frequency also increased during the second stage and correlated significantly (r2 = 0.60; P = .0006) with levels of PRL. Levels of hCG increased during labor and peaked at about the time of delivery.
CONCLUSION
These data suggest that phasic PRL secretion is associated with cervical dilatation and that after transition to the second stage of labor, uterine contraction frequency may be associated with the increase in PRL levels.
目的
在本研究中，我们试图确定催乳素（PRL）和人绒毛膜促性腺激素（hCG）在分娩过程中的生理作用。
方法
收集19名女性（15名经产妇和4名初产妇）分娩前、分娩期间和分娩后的系列血样；检测PRL和hCG；并与宫颈扩张和子宫收缩频率进行比较。
结果
在分娩第一阶段，催乳素水平随着宫颈的逐渐扩张而下降，在完全扩张时达到最低点。此后，催乳素在分娩第二阶段迅速升高，并在产后1小时内达到峰值。子宫收缩频率在第二阶段也增加，并且与催乳素水平显著相关（r2 = 0.60；P = .0006）。hCG水平在分娩期间升高，并在分娩时左右达到峰值。
结论
这些数据表明，阶段性催乳素分泌与宫颈扩张有关，并且在过渡到分娩第二阶段后，子宫收缩频率可能与催乳素水平的升高有关。
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