玻璃对伤寒疫苗pH依赖性稳定性的影响。
Effect of glass on pH-dependent stability of typhoid vaccine.
作者信息
Driesens R J
出版信息
J Clin Microbiol. 1976 Aug;2(2):85-8.
Abstract
Vaccines made from the Ty-2 strain of Salmonella typhosa were tested periodically for stability of pH and of potency. The acetone-treated cultures prepared in buffered saline solutions retained potency beyond 30 months of storage at 0 to 5 C. Similar vaccines in unbuffered saline solutions lost potency coincident with increase of alkalinity. Vaccines packaged in United States Pharmacopeia borosilicate glass vials retained potency and pH stability, whereas those in Type III United States Pharmacopeia soda-lime glass vials were less stable.
摘要
对由伤寒沙门氏菌Ty-2菌株制成的疫苗进行了pH值和效力稳定性的定期测试。在缓冲盐溶液中制备的经丙酮处理的培养物在0至5摄氏度下储存超过30个月后仍保持效力。在无缓冲盐溶液中的类似疫苗随着碱度的增加而失去效力。包装在美国药典硼硅酸盐玻璃瓶中的疫苗保持了效力和pH稳定性，而包装在美国药典III型钠钙玻璃瓶中的疫苗则稳定性较差。
相似文献
1
Effect of glass on pH-dependent stability of typhoid vaccine.玻璃对伤寒疫苗pH依赖性稳定性的影响。
J Clin Microbiol. 1976 Aug;2(2):85-8.
2
Characteristics of the attenuated oral vaccine strain "S. typhi" Ty 21a.减毒口服疫苗株“伤寒沙门氏菌”Ty 21a的特性。
Dev Biol Stand. 1983;53:3-7.
3
Factors influencing the stability of live oral attenuated bacterial vaccines.影响口服减毒活细菌疫苗稳定性的因素。
Dev Biol Stand. 1996;87:277-81.
4
[Stability of cyclodrin hydrochloride. 3: Stability of cyclodrin hydrochloride as a substance and in ophthalmologic solutions. 51: Contributions to problems concerning the use of plastic receptacles for liquid pharmaceuticals].[盐酸环多林的稳定性。3：盐酸环多林作为一种物质及其在眼科溶液中的稳定性。51：关于液体药物塑料容器使用问题的研究报告]
Pharmazie. 1982 Nov;37(11):773-6.
5
Assay of typhoid vaccines with Salmonella typhosa-Salmonella typhimurium hybrids.用伤寒沙门氏菌-鼠伤寒沙门氏菌杂交菌株检测伤寒疫苗
Infect Immun. 1973 Jan;7(1):5-8. doi: 10.1128/iai.7.1.5-8.1973.
6
Container effects on the physicochemical properties of parenteral lipid emulsions.容器对肠外脂质乳剂物理化学性质的影响。
Nutrition. 2008 Nov-Dec;24(11-12):1182-8. doi: 10.1016/j.nut.2008.06.003. Epub 2008 Aug 15.
7
8
Accelerated extractable studies of borosilicate glass containers.硼硅酸盐玻璃容器的加速可提取物研究。
J Parenter Sci Technol. 1989 Mar-Apr;43(2):67-79.
9
Evaluation of phoP and rpoS mutants of Salmonella enterica serovar Typhi as attenuated typhoid vaccine candidates: virulence and protective immune responses in intranasally immunized mice.肠炎沙门氏菌伤寒血清型phoP和rpoS突变体作为减毒伤寒疫苗候选株的评价：鼻内免疫小鼠的毒力和保护性免疫反应
FEMS Immunol Med Microbiol. 2007 Nov;51(2):310-8. doi: 10.1111/j.1574-695X.2007.00307.x. Epub 2007 Aug 24.
10
Temperature-sensitive vaccine strains of "Salmonella typhi".伤寒沙门氏菌的温度敏感疫苗株。
Ann Sclavo Collana Monogr. 1986;3(1-2):23-30.
本文引用的文献
1
Preservation of typhoid vaccine.伤寒疫苗的保存
Lancet. 1951 Mar 17;1(6655):618-9. doi: 10.1016/s0140-6736(51)91121-x.
2
Studies on Vi antigen. VIII. Role of acetyl in antigenic activity.Vi抗原研究。VIII. 乙酰基在抗原活性中的作用。
Am J Hyg. 1961 Jan;73:55-65.
3
Studies on Vi antigen. VII. Characteristics of the immune response in the mouse.Vi抗原研究。VII. 小鼠免疫反应的特征。
Am J Hyg. 1957 Jan;65(1):81-93. doi: 10.1093/oxfordjournals.aje.a119858.
4
The influence of storage on the antibody-stimulating properties of different typhoid vaccines.储存对不同伤寒疫苗抗体刺激特性的影响。
Acta Pathol Microbiol Scand. 1956;38(1):73-80. doi: 10.1111/j.1699-0463.1956.tb03164.x.
5
Duration of potency of T.A.B. vaccine stored at room temperature.在室温下储存的伤寒副伤寒甲、乙三联疫苗的效力持续时间。
Indian J Med Res. 1955 Jul;43(3):375-7.
6
Enhancement of the immunogenicity of typhoid vaccine by retention of the V1 antigen.通过保留V1抗原增强伤寒疫苗的免疫原性。
Am J Hyg. 1953 Sep;58(2):148-64. doi: 10.1093/oxfordjournals.aje.a119596.
7
Physiochemical properties of the Vi antigen before and after mild alkaline hydrolysis.轻度碱水解前后Vi抗原的理化性质
J Bacteriol. 1967 Nov;94(5):1406-10. doi: 10.1128/jb.94.5.1406-1410.1967.
8
On vaccines and vaccination: typhoid-paratyphoid fevers.关于疫苗与预防接种：伤寒和副伤寒热
Postgrad Med J. 1972 Feb;48(556):98-106. doi: 10.1136/pgmj.48.556.98.
9
Effect of a Vi-degrading enzyme on potency of typhoid vaccines in mice.一种Vi降解酶对小鼠伤寒疫苗效力的影响。
J Infect Dis. 1972 Apr;125(4):360-6. doi: 10.1093/infdis/125.4.360.
10
Adhesion of Vi antigen and toxicity in typhoid vaccines inactivated by acetone or by heat and phenol.伤寒疫苗中Vi抗原的黏附性以及经丙酮或热酚灭活后的毒性
J Infect Dis. 1974 May;129(5):501-6. doi: 10.1093/infdis/129.5.501.
Zotero 插件