白细胞去除与储存之间的关系。

Relation between leucocyte depletion and storage.

作者信息

Weisbach V, Riewald M, Zingsem J, Putzo A, Zimmermann R, Zeiler T, Riess H, Eckstein R

机构信息

Abteilung für Transfusionsmedizin, Chirurgische Klinik, FAU Erlangen-Nürnberg.

出版信息

Beitr Infusionsther Transfusionsmed. 1994;32:69-72.

PMID:9422103

Abstract

We intended to answer two questions: (1) Does storage time of platelet concentrates (PCs) influence the efficacy of leucocyte depletion by filtration? (2) Does pre-storage leucocyte depletion by filtration of PCs improve the post-storage quality? To this end we tested in parallel the halves of 10 double-sized PCs, one half stored after filtration through a polyester filter (PL 50, Pall), the other half filtered after a 5-day storage period. Efficacy of leucocyte depletion showed to be independent of the age of PCs, and pre-storage leucocyte depletion of PCs was not able to improve the quality of PCs stored for 5 days, as long as the leucocyte contamination of unfiltered PCs was lower than 0.5 x 10(8)/unit.

摘要

我们旨在回答两个问题

（1）血小板浓缩物（PCs）的储存时间是否会影响过滤去除白细胞的效果？（2）对PCs进行储存前过滤去除白细胞是否能改善储存后的质量？为此，我们对10个双倍量的PCs进行了平行测试，一半在通过聚酯过滤器（PL 50，颇尔公司）过滤后储存，另一半在储存5天后进行过滤。结果表明，去除白细胞的效果与PCs的储存时间无关，并且只要未过滤的PCs中的白细胞污染低于0.5×10⁸/单位，对PCs进行储存前过滤去除白细胞并不能改善储存5天的PCs的质量。