Zeimer H J, Greenaway T M, Slavin J, Hards D K, Zhou H, Doery J C, Hunter A N, Duffield A, Martin T J, Grill V
St. Vincent's Hospital, Fitzroy, Australia.
Am J Pathol. 1998 Jan;152(1):17-21.
Parathyroid-hormone-related protein (PTHrP) is the main mediator of the humoral hypercalcemia of malignancy. It is also detected in many normal adult and fetal tissues. Altered calcium metabolism occurs in sarcoidosis, and two cases of sarcoidosis with hypercalcemia and elevated plasma PTHrP are described. An archival study of 20 lymph node biopsies with the pathological diagnosis of sarcoidosis was performed. Immunohistochemistry using a polyclonal antiserum to human PTHrP and in situ hybridization using a riboprobe to human PTHrP were performed on the lymph node biopsies. Immunohistochemistry for PTHrP was also performed on the biopsies from the two cases with elevated plasma levels. Immunohistochemical analysis detected PTHrP in macrophages within granulomata in 17 of the 20 (85%) biopsies. In situ hybridization detected a positive signal for messenger RNA in the granulomata of 11 of 19 (58%) biopsies. PTHrP immunoreactivity and PTHrP gene expression are present in sarcoid granulomata. PTHrP may contribute to the hypercalcemia of sarcoidosis.
甲状旁腺激素相关蛋白（PTHrP）是恶性肿瘤体液性高钙血症的主要介质。它也在许多正常成人及胎儿组织中被检测到。结节病中会出现钙代谢改变，本文描述了两例伴有高钙血症和血浆PTHrP升高的结节病病例。对20例经病理诊断为结节病的淋巴结活检标本进行了存档研究。对淋巴结活检标本进行了使用抗人PTHrP多克隆抗血清的免疫组织化学检测以及使用人PTHrP核糖探针的原位杂交检测。对两例血浆水平升高病例的活检标本也进行了PTHrP免疫组织化学检测。免疫组织化学分析在20例活检标本中的17例（85%）的肉芽肿内巨噬细胞中检测到了PTHrP。原位杂交在19例活检标本中的11例（58%）的肉芽肿中检测到信使核糖核酸的阳性信号。结节病肉芽肿中存在PTHrP免疫反应性和PTHrP基因表达。PTHrP可能与结节病的高钙血症有关。
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