Sanderson C R, Davis R E, Bayliss C E
Ann Rheum Dis. 1976 Apr;35(2):177-80. doi: 10.1136/ard.35.2.177.
Abnormalities of tryptophan metabolism have been reported in patients with rheumatoid arthritis (RA) and it has been suggested that these abnormalities are the result of disordered vitamin B6 metabolism. Fasting serum pyridoxal, assayed by an automated microbiological system, was found to be below normal in 35 out of 42 patients with RA while a similar abnormality was found in 8 out of 35 patients with osteoarthrosis (OA). Within the RA group the abnormality could not be related to the age, sex, or drug therapy of individuals but of the 8 patients with OA and a low serum pyridoxal, 7 were receiving indomethacin either alone or in conjunction with aspirin.
类风湿性关节炎（RA）患者中已报告有色氨酸代谢异常，并且有人提出这些异常是维生素B6代谢紊乱的结果。通过自动微生物系统检测的空腹血清吡哆醛，在42例RA患者中有35例低于正常水平，而在35例骨关节炎（OA）患者中有8例发现类似异常。在RA组中，这种异常与个体的年龄、性别或药物治疗无关，但在8例血清吡哆醛水平低的OA患者中，有7例正在单独服用吲哚美辛或与阿司匹林联合服用。
