Department of Biotechnology, Institute of Biosciences and Biotechnology, Chhatrapati Shahu Ji Maharaj University, Kanpur, Uttar Pradesh, India.
Rheumatol Int. 2012 Aug;32(8):2377-82. doi: 10.1007/s00296-011-1964-1. Epub 2011 Jun 5.
Progression of rheumatoid arthritis (RA) and osteoarthritis (OA) is associated with inflammation and oxidative stress. Previous studies have shown that there was no difference between RA and OA patients regarding the percentages of the different lymphocytes subsets reflecting the abnormalities in T cells and its subsets that may contribute to the pathogenesis of OA as in RA. Therefore, the present study was aimed to analyze that whether disease activity of OA is able to affect a few serological and biochemical parameters in the same way as RA does or differently. The study was done on 36 asymptomatic controls (25 women), 28 patients with OA (20 women), 36 patients with RA (22 women). Patients with OA were screened according to radiological and clinical finding of Kellgren and Lawrence grade and ACR criteria and assessed by VAS and WOMAC score. Patients with RA were selected who were fulfilling 4/5 symptoms of ACR criteria, and their DAS28-CRP, VAS score, and RF positivity were evaluated. Participants of the groups were matched for sex, age, weight, and height (body mass index). The BMI of all three groups was also found to be the same (P > 0.05). The mean level of LDL, cholesterol, MDA, CRP, and triglyceride was significantly (P < 0.05 or P < 0.01) higher in both OA and RA as compared to control. The mean level of total lipid, cholesterol, MDA, CRP, and triglyceride was found to be significantly (P < 0.05 or P < 0.01) higher in RA as compared to OA. The pre-treatment CRP level of both groups of patients showed significant and direct relation with total lipid (r = 0.27, P < 0.05) and cholesterol (r = 0.66, P < 0.01). Inverse relation was observed between uric acid and creatinine (r = -0.26, P < 0.05) and cholesterol and HDL (r = -0.34, P < 0.01). Our study shows the similar trend in lipid profile and other parameters studied in both patients with OA and patients with RA with more pronounced changes in RA.
类风湿关节炎 (RA) 和骨关节炎 (OA) 的进展与炎症和氧化应激有关。先前的研究表明，RA 和 OA 患者之间反映 T 细胞及其亚群异常的不同淋巴细胞亚群的百分比没有差异，这些异常可能导致 OA 的发病机制与 RA 相同。因此，本研究旨在分析 OA 的疾病活动是否能够以与 RA 相同的方式或不同的方式影响一些血清学和生化参数。研究对象为 36 名无症状对照者（25 名女性）、28 名 OA 患者（20 名女性）和 36 名 RA 患者（22 名女性）。根据 Kellgren 和 Lawrence 分级和 ACR 标准的影像学和临床发现筛选 OA 患者，并通过 VAS 和 WOMAC 评分进行评估。RA 患者的选择标准是符合 ACR 标准的 4/5 种症状，评估其 DAS28-CRP、VAS 评分和 RF 阳性率。各组参与者的性别、年龄、体重和身高（体重指数）相匹配。三组的 BMI 也相同（P > 0.05）。与对照组相比，OA 和 RA 患者的 LDL、胆固醇、MDA、CRP 和甘油三酯的平均水平显著升高（P < 0.05 或 P < 0.01）。与 OA 相比，RA 患者的总脂质、胆固醇、MDA、CRP 和甘油三酯的平均水平显著升高（P < 0.05 或 P < 0.01）。两组患者的治疗前 CRP 水平与总脂质（r = 0.27，P < 0.05）和胆固醇（r = 0.66，P < 0.01）呈显著正相关。尿酸与肌酐之间呈负相关（r = -0.26，P < 0.05），胆固醇与 HDL 之间呈负相关（r = -0.34，P < 0.01）。我们的研究表明，OA 和 RA 患者的脂质谱和其他研究参数有相似的趋势，RA 患者的变化更为明显。
