Quitkin F, Rifkin A, Klein D F
Arch Gen Psychiatry. 1976 Jul;33(7):845-53. doi: 10.1001/archpsyc.1976.01770070075008.
Previous studies indicated that for two subgroups of patients, schizophrenics with premorbid asociality (SPA) and individuals with emotionally unstable character disorders (EUCD), central nervous system damage may have etiologic significance. It was hypothesized that these two patient groups would also have an increased number of neurologic soft signs. The relationship of neurologic examination, tests of auditory-visual integration, and intelligence quotient, and diagnoses was studied for 350 patients. Tests of reliability and persistence for all observed signs were performed. The EUCD and SPA groups had increased evidence of neurologic soft signs. Differences in patterns of IQ scores also suggest that different forms of brain damage may be present in these two groups. When the two groups were removed from the larger patient sample, those patients with other types of schizophrenia and character disorder did not exhibit evidence of neurologic impairment. This study of neurologic soft signs adds to the validity of considering SPA and EUCD as separate diagnostic entities.
先前的研究表明，对于两组患者，即病前有反社会行为的精神分裂症患者（SPA）和患有情绪不稳定型人格障碍的个体（EUCD），中枢神经系统损伤可能具有病因学意义。据推测，这两组患者的神经学软体征数量也会增加。对350名患者的神经学检查、视听整合测试、智商和诊断之间的关系进行了研究。对所有观察到的体征进行了可靠性和持续性测试。EUCD组和SPA组有更多神经学软体征的证据。智商分数模式的差异也表明，这两组可能存在不同形式的脑损伤。当将这两组从更大的患者样本中剔除后，其他类型的精神分裂症和人格障碍患者未表现出神经功能损害的证据。这项关于神经学软体征的研究增加了将SPA和EUCD视为独立诊断实体的有效性。
