Lockwood G G, Dob D P, Bryant D J, Wilson J A, Sargentoni J, Sapsed-Byrne S M, Harris D N, Menon D K
Department of Anaesthesia, Hammersmith Hospital, London.
Br J Anaesth. 1997 Nov;79(5):586-9. doi: 10.1093/bja/79.5.586.
We describe the first experiments to relate the cerebral kinetics of isoflurane (determined by fluorine magnetic resonance spectroscopy) to cerebral function. Using a surface receive coil we found two-compartment kinetics within the head with equilibrium half-times of 3.5 min and approximately 1 h with respect to expired isoflurane concentrations. Using critical fusion flicker frequency as an objective measure of the cerebral effect of isoflurane, we found evidence to identify the fast component as the brain. Responsiveness to command was lost at a brain partial pressure of 0.3% isoflurane. We conclude that the measured cerebral kinetics of isoflurane exactly matched the predictions of the classical perfusion-limited model.
我们描述了首例将异氟烷的脑动力学（通过氟磁共振波谱法测定）与脑功能相关联的实验。使用表面接收线圈，我们发现头部内存在双室动力学，相对于呼出的异氟烷浓度，平衡半衰期分别为3.5分钟和约1小时。使用临界融合闪烁频率作为异氟烷脑效应的客观指标，我们发现有证据表明快速成分与脑相关。在脑异氟烷分压为0.3%时，对指令的反应消失。我们得出结论，所测得的异氟烷脑动力学与经典灌注限制模型的预测完全相符。
