Venkatasubramanian P N, Shen Y J, Wyrwicz A M
Evanston Hospital, Department of Anesthesia, Illinois, USA.
Magn Reson Med. 1996 Apr;35(4):626-30. doi: 10.1002/mrm.1910350426.
The distribution of two fluorinated anesthetics, halothane and isoflurane, in rabbit brain was mapped during the course of their uptake using 19F NMR chemical shift imaging techniques. Use of a short phase-encoding time and free induction decay acquisition minimized T2-related signal losses in two-dimensional chemical shift imaging. Localization of the brain and exclusion of surrounding tissues was achieved by the use of a surface coil. The spatial distribution of halothane and isoflurane in the brain was nonuniform and both anesthetics were detected predominantly in the cerebral cortex. During the early stages of uptake, anesthetic concentration in the brain was extremely low, but it continued to increase for several hours with sustained anesthetic delivery. Time-dependent variations in anesthetic concentration were observed in different brain regions.
利用19F核磁共振化学位移成像技术，在两种含氟麻醉剂氟烷和异氟烷的摄取过程中，绘制了它们在兔脑中的分布图。在二维化学位移成像中，使用短相位编码时间和自由感应衰减采集，将与T2相关的信号损失降至最低。通过使用表面线圈实现了脑的定位和周围组织的排除。氟烷和异氟烷在脑中的空间分布不均匀，两种麻醉剂主要在大脑皮层中被检测到。在摄取的早期阶段，脑中的麻醉剂浓度极低，但随着持续给予麻醉剂，其浓度持续增加数小时。在不同脑区观察到了麻醉剂浓度随时间的变化。
