Lockwood G G, Dob D P, Bryant D J, Wilson J A, Sargentoni J, Sapsed-Byrne S M, Harris D N, Menon D K
Department of Anaesthesia, Hammersmith Hospital, London.
Br J Anaesth. 1997 Nov;79(5):581-5. doi: 10.1093/bja/79.5.581.
We describe the first human experiments to demonstrate wash-out of isoflurane using fluorine magnetic resonance spectroscopy. Using a surface receive coil, we found two-compartment kinetics within the head with decay half-times of 9.5 and 130 min, but the signal was too weak to localize the compartments. If the fast compartment is assumed to be the brain then our results match the predictions of the classical perfusion-limited pharmacokinetic model of inhalation anaesthesia.
我们描述了首次利用氟磁共振波谱证明异氟烷清除的人体实验。使用表面接收线圈，我们发现头部存在两室动力学，衰减半衰期分别为9.5分钟和130分钟，但信号太弱无法确定这些室的位置。如果假设快速室为脑，那么我们的结果与吸入麻醉经典灌注限制药代动力学模型的预测相符。
