Jackson A, Sheppard S, Laitt R D, Kassner A, Moriarty D
Department of Diagnostic Radiology, University of Manchester, England.
Radiology. 1998 Jan;206(1):57-63. doi: 10.1148/radiology.206.1.9423652.
To examine the benefits of combined fat- and water-suppressed T2-weighted magnetic resonance (MR) images in the diagnosis of optic neuritis.
MR imaging was performed with a 1.5-T unit in five healthy volunteers and 18 patients (21 nerves). All patients had abnormalities of visual evoked potentials and fulfilled the clinical criteria for the diagnosis of optic neuritis. Imaging was performed within 4 weeks of diagnosis (n = 12) or between 3 and 6 months after diagnosis (n = 6). Coronal images were obtained throughout the course of the optic nerve with use of three sequences: (a) short inversion time inversion recovery with fast spin-echo (SE) acquisition, (b) selective partial inversion-recovery (SPIR) prepared T2-weighted fast SE acquisition, and (c) SPIR-fluid-attenuated inversion recovery (FLAIR) with fast SE acquisition.
Neuritic segments were demonstrated in all 21 symptomatic nerves. The extent of neuritic involvement (number of images showing abnormality) was significantly greater with the SPIR-FLAIR sequence (P < .01). The contrast ratio between neuritic optic nerve and orbital fat, normal nerve, and cerebral spinal fluid was significantly greater with SPIR-FLAIR than with the other sequences (P < .001). SPIR-FLAIR images also improved demonstration of optic nerve atrophy in chronic neuritis when compared with the other sequences.
The SPIR-FLAIR sequence offers important advantages over current methods in the demonstration of optic neuritis.
探讨脂肪抑制和水抑制相结合的T2加权磁共振（MR）图像在视神经炎诊断中的作用。
对5名健康志愿者和18例患者（21条神经）采用1.5-T设备进行MR成像。所有患者视觉诱发电位均异常，符合视神经炎的临床诊断标准。在诊断后4周内（n = 12）或诊断后3至6个月之间（n = 6）进行成像。使用三个序列在整个视神经行程中获取冠状位图像：（a）短反转时间反转恢复序列结合快速自旋回波（SE）采集，（b）选择性部分反转恢复（SPIR）准备的T2加权快速SE采集，以及（c）SPIR液体衰减反转恢复（FLAIR）结合快速SE采集。
在所有21条有症状的神经中均显示出神经炎性节段。SPIR-FLAIR序列显示的神经炎性累及范围（显示异常的图像数量）明显更大（P <.01）。SPIR-FLAIR序列显示的炎性视神经与眶内脂肪、正常神经和脑脊液之间的对比度明显高于其他序列（P <.001）。与其他序列相比，SPIR-FLAIR图像在显示慢性神经炎的视神经萎缩方面也更具优势。
在视神经炎的显示方面，SPIR-FLAIR序列比现有方法具有重要优势。
