Kent D G, Peng Q, Isaacs R T, Whiteside S B, Barker D L, Apple D J
Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston 29425-2236, USA.
J Cataract Refract Surg. 1997 Nov;23(9):1371-5. doi: 10.1016/s0886-3350(97)80116-2.
To assess the effect of relatively large positioning holes on the security of capsular bag fixation of plate-haptic silicone intraocular lenses (IOLs).
Center for Research on Ocular Therapeutics and Biodevices, Department of Ophthalmology, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA.
This study tested the hypothesis that larger holes allow ingrowth of lens material, fibrous tissue, or both through them, which helps fixate the lens more firmly in the capsular bag. Five rabbits had bilateral continuous curvilinear capsulorhexis, phacoemulsification, and implantation of a plate-haptic silicone IOL. An IOL with a small, round positioning hole (Staar AA-4203V) was implanted in the right eye in each rabbit, and a large-hole IOL (Staar AA-4203VF) was implanted in the left eye. After 2 months, all rabbits were killed. The force required to extract one haptic from the capsular bag was measured with a digital force meter. All eyes had histopathological analysis.
It was slightly more difficult to extract a large-hole IOL from the capsular bag, although this trend was not statistically significant. However, histopathological analysis consistently showed 360 degree synechia formation through the holes, showing that the IOL could be securely fixed in position.
Proliferation of lens epithelial cells through a large positioning hole in a plate-haptic silicone IOL may improve the long-term security of capsular bag fixation. This will help reduce the incidence of IOL decentration and dislocation.
评估相对较大的定位孔对板袢硅凝胶人工晶状体（IOL）囊袋固定安全性的影响。
美国南卡罗来纳州查尔斯顿市南卡罗来纳医科大学风暴眼研究所眼科眼部治疗与生物装置研究中心。
本研究检验了以下假设，即较大的孔允许晶状体材料、纤维组织或两者通过，这有助于将晶状体更牢固地固定在囊袋中。5只兔子接受了双侧连续环形撕囊、超声乳化及板袢硅凝胶IOL植入术。每只兔子的右眼植入一个带有小圆形定位孔的IOL（Staar AA - 4203V），左眼植入一个大孔IOL（Staar AA - 4203VF）。2个月后，所有兔子均被处死。使用数字测力计测量从囊袋中拔出一个袢所需的力。所有眼睛均进行了组织病理学分析。
从囊袋中拔出大孔IOL稍困难一些，尽管这一趋势无统计学意义。然而，组织病理学分析一致显示通过这些孔形成了360度的虹膜粘连，表明IOL可牢固固定在位。
晶状体上皮细胞通过板袢硅凝胶IOL上的大定位孔增殖可能会提高囊袋固定的长期安全性。这将有助于降低IOL偏心和脱位的发生率。
