Whiteside S B, Apple D J, Peng Q, Isaacs R T, Guindi A, Draughn R A
Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Charleston, South Carolina 29425-2236, USA.
Ophthalmology. 1998 May;105(5):837-42. doi: 10.1016/S0161-6420(98)95022-9.
This study aimed to evaluate in rabbit eyes the effects of large positioning holes in one-piece silicone plate-haptic intraocular lenses (IOLs) with respect to security of capsular bag fixation. Mechanical strength of capsular fixation is correlated with the histologic findings of regenerating lens material and fibrous tissue ingrowth through the positioning holes on silicone plate IOLs, comparing capsules implanted with large-hole style plate IOLs to fellow capsules implanted with small-hole style plate IOLs.
The study design was a prospective, randomized, experimental study.
A total of 40 fellow capsular bags from 20 New Zealand white rabbits were examined. Capsules implanted with conventional small-hole silicone plate IOLs were used as the control in all pairs of fellow capsules.
Phacoemulsification and implantation of a silicone plate IOL with small positioning holes in one eye and implantation of a silicone plate IOL with large positioning holes in the fellow eye were measured. All rabbits were killed at 2 months. The force required to extract the IOLs from the capsular bag was measured. All capsular bags underwent histopathologic analysis.
Extraction force measurements and histopathologic examination, comparing capsules implanted with small-hole plate IOLs with fellow capsules implanted with large-hole plate IOLs, were measured.
The large-hole style IOL required significantly more force to extract from the capsular bag compared to the conventional small-hole style (P = 0.003). Histologically, proliferating lens epithelial material and fibrous tissue were observed growing through all of the large positioning holes (synechia formation) but not through any of the small positioning holes.
Silicone plate IOLs with large positioning holes become affixed more firmly within the capsular bag compared to conventional small-hole plate IOLs. These findings suggest that large holes in silicone plate IOLs allow for superior capsular bag fixation. This should reduce the rates of decentration and dislocation.
本研究旨在评估一体式硅胶板袢人工晶状体（IOL）上的大定位孔对兔眼囊袋固定安全性的影响。通过比较植入大孔型板IOL的囊袋与植入小孔型板IOL的对侧囊袋，囊袋固定的机械强度与再生晶状体材料的组织学发现以及纤维组织通过硅胶板IOL上的定位孔向内生长有关。
研究设计为前瞻性、随机、实验性研究。
检查了来自20只新西兰白兔的总共40对囊袋。在所有对侧囊袋中，植入传统小孔硅胶板IOL的囊袋用作对照。
测量一只眼行超声乳化并植入带小定位孔的硅胶板IOL，对侧眼植入带大定位孔的硅胶板IOL。所有兔子在2个月时处死。测量从囊袋中取出IOL所需的力。所有囊袋均进行组织病理学分析。
测量取出力并进行组织病理学检查，比较植入小孔板IOL的囊袋与植入大孔板IOL的对侧囊袋。
与传统小孔型IOL相比，大孔型IOL从囊袋中取出所需的力明显更大（P = 0.003）。组织学上，观察到增殖的晶状体上皮材料和纤维组织通过所有大定位孔生长（形成粘连），但未通过任何小定位孔。
与传统小孔板IOL相比，带大定位孔的硅胶板IOL在囊袋内固定更牢固。这些发现表明，硅胶板IOL上的大孔可实现更好的囊袋固定。这应能降低偏心和脱位的发生率。
Zotero 插件