Kent D G, Peng Q, Isaacs R T, Whiteside S B, Barker D L, Apple D J
Department of Ophthalmology, Storm Eye Institute, Medical University of South Carolina, Charleston 29425-2236, USA.
J Cataract Refract Surg. 1998 May;24(5):666-71. doi: 10.1016/s0886-3350(98)80263-0.
To evaluate the effects of a new mini-haptic design on the strength and stability of capsular bag fixation of plate-haptic silicone intraocular lenses (IOLs) and determine whether this design encourages the growth of regenerating lens material or fibrous tissue around the haptic biomaterial and thus improves lens fixation in the capsular bag.
Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Department of Ophthalmology, Charleston, South Carolina, USA.
Six rabbits had bilateral continuous curvilinear capsulorhexis, phacoemulsification, and plate-haptic silicone IOL implantation. Each rabbit had a small-hole plate IOL (Chiron C10UB) implanted in the right eye and a mini-haptic plate IOL (Chiron C40UB) in the left eye. All rabbits were killed at 2 months. The force required to extract one haptic from the capsular bag was measured with a digital force gauge. Histopathologic analysis was performed on all specimens.
The mini-haptic style IOLs required significantly more extraction force than the small-hole design (P = .011). Histopathologically, proliferating lens epithelial cells were observed growing circumferentially around the mini-haptics, causing a 360 degree synechia formation. This formation did not occur with the conventional small-hole plate IOLs used as the control.
Lens epithelial cell proliferation around the mini-haptics significantly improved capsular bag fixation of the plate-haptic silicone IOL. This should decrease the incidence of clinical decentration and dislocation.
评估一种新型微触觉设计对板式触觉硅酮人工晶状体（IOL）囊袋固定强度和稳定性的影响，并确定该设计是否会促进触觉生物材料周围再生晶状体物质或纤维组织的生长，从而改善人工晶状体在囊袋内的固定。
美国南卡罗来纳州查尔斯顿市南卡罗来纳医科大学风暴眼研究所眼治疗与生物装置研究中心眼科。
6只兔子接受双侧连续环形撕囊、超声乳化和板式触觉硅酮人工晶状体植入。每只兔子右眼植入小孔板式人工晶状体（Chiron C10UB），左眼植入微触觉板式人工晶状体（Chiron C40UB）。所有兔子在2个月时处死。用数字测力计测量从囊袋中拔出一个触觉所需的力。对所有标本进行组织病理学分析。
微触觉式人工晶状体所需的拔出力明显高于小孔设计（P = 0.011）。组织病理学上，观察到增殖的晶状体上皮细胞围绕微触觉呈圆周生长，导致360度虹膜粘连形成。用作对照的传统小孔板式人工晶状体未出现这种情况。
微触觉周围的晶状体上皮细胞增殖显著改善了板式触觉硅酮人工晶状体在囊袋内的固定。这应会降低临床偏心和脱位的发生率。
