• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Effects of clofibrate on some microsomal hydroxylations involved in the formation and metabolism of bile acids in rat liver.氯贝丁酯对大鼠肝脏中参与胆汁酸形成和代谢的某些微粒体羟化作用的影响。
Biochem J. 1976 May 15;156(2):445-8. doi: 10.1042/bj1560445.
2
The metabolism of steroids in the fatty liver induced by orotic acid feeding.乳清酸喂养诱导的脂肪肝中类固醇的代谢
Biochem J. 1976 Jul 15;158(1):89-95. doi: 10.1042/bj1580089.
3
Influence of fructose feeding on individual enzymic reactions in the formation and metabolism of bile acids in rat liver homogenates.果糖喂养对大鼠肝脏匀浆中胆汁酸形成和代谢过程中各个酶促反应的影响。
Br J Nutr. 1976 Sep;36(2):273-9. doi: 10.1079/bjn19760079.
4
Influence of cholesterol feeding on liver microsomal metabolism of steroids and bile acids in conventional and germ-free rats.胆固醇喂养对普通大鼠和无菌大鼠肝脏微粒体中类固醇及胆汁酸代谢的影响。
J Biol Chem. 1975 Nov 10;250(21):8496-502.
5
Distinct forms of cytochrome P-450 are responsible for 6 beta-hydroxylation of bile acids and of neutral steroids.细胞色素P-450的不同形式负责胆汁酸和中性类固醇的6β-羟基化。
Biochem J. 1991 Apr 1;275 ( Pt 1)(Pt 1):105-11. doi: 10.1042/bj2750105.
6
Biosynthesis of bile acids in man. Hydroxylation of the C27-steroid side chain.人体内胆汁酸的生物合成。C27甾体侧链的羟基化作用。
J Clin Invest. 1975 Mar;55(3):478-86. doi: 10.1172/JCI107954.
7
Studies on the 12alpha and 26-hydroxylation of bile alcohols by rabbit liver microsomes.兔肝微粒体对胆汁醇的12α和26-羟基化作用的研究。
Lipids. 1976 Feb;11(2):148-52. doi: 10.1007/BF02532665.
8
Effects of long term feeding of chenodeoxycholic acid on biosynthesis and metabolism of bile acids in the rat.长期投喂鹅去氧胆酸对大鼠胆汁酸生物合成及代谢的影响。
Gastroenterology. 1974 Jul;67(1):126-34.
9
Biosynthesis of bile acids in cerebrotendinous xanthomatosis. Relationship of bile acid pool sizes and synthesis rates to hydroxylations at C-12, C-25, and C-26.脑腱黄瘤病中胆汁酸的生物合成。胆汁酸池大小和合成速率与C-12、C-25和C-26位羟基化的关系。
J Clin Invest. 1985 Aug;76(2):744-51. doi: 10.1172/JCI112030.
10
Effect of biliary obstruction on 26-hydroxylation of C27-steroids in bile acid synthesis.胆汁淤积对胆汁酸合成中C27-类固醇26-羟化作用的影响。
J Lipid Res. 1978 Feb;19(2):237-43.

引用本文的文献

1
Effects of clofibrate and tiadenol on the elimination of lipids and bile acids in rat bile.氯贝丁酯和替阿地诺对大鼠胆汁中脂质和胆汁酸排泄的影响。
Lipids. 1981 Oct;16(10):732-8. doi: 10.1007/BF02535340.
2
Effects of bezafibrate on hepatic cholesterol metabolism.苯扎贝特对肝脏胆固醇代谢的影响。
Eur J Clin Pharmacol. 1991;40 Suppl 1:S33-6. doi: 10.1007/BF01409405.
3
Bile formation and biliary lipid composition under the influence of clofibrate and phenobarbital pretreatment in the rat.氯贝丁酯和苯巴比妥预处理对大鼠胆汁生成及胆汁脂质成分的影响
Naunyn Schmiedebergs Arch Pharmacol. 1979 Aug;308(2):171-7. doi: 10.1007/BF00499061.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
HYPOLIPEMIA AND HEPATOMEGALY FROM ETHYL CHLOROPHENOXYISOBUTYRATE (CPIB) IN THE RAT.大鼠中氯苯氧异丁酸乙酯（CPIB）导致的低脂血症和肝肿大
J Lab Clin Med. 1964 Oct;64:634-42.
3
Modification of metabolism and distribution of lipids by ethyl chlorophenoxyisobutyrate.氯苯丁酯对脂质代谢及分布的影响
Nature. 1962 Jun 9;194:948-9. doi: 10.1038/194948a0.
4
Effect of carbon monoxide and phenobarbital on hydroxylation of bile acids by rat liver microsomes.一氧化碳和苯巴比妥对大鼠肝微粒体胆汁酸羟化作用的影响。
FEBS Lett. 1969 Aug;4(3):177-180. doi: 10.1016/0014-5793(69)80228-0.
5
Effects of thyroidectomy and thyroxine treatment on the activity of 12alpha-hydroxylase and of some components of microsomal electron transfer chains in rat liver.甲状腺切除及甲状腺素治疗对大鼠肝脏12α-羟化酶活性及微粒体电子传递链某些成分的影响。
FEBS Lett. 1968 Jul;1(1):13-15. doi: 10.1016/0014-5793(68)80006-7.
6
Nature of the hepatomegalic effect produced by ethyl-chlorophenoxy-isobutyrate in the rat.氯苯丁酯在大鼠体内产生肝肿大效应的性质。
Nature. 1965 Nov 27;208(5013):856-8. doi: 10.1038/208856a0.
7
Effect of cholestyramine and diet on hydroxylations in the biosynthesis and metabolism of bile acids.消胆胺和饮食对胆汁酸生物合成及代谢中羟化作用的影响。
Eur J Biochem. 1970 Dec;17(2):292-5. doi: 10.1111/j.1432-1033.1970.tb01167.x.
8
Effect of clofibrate and 1-methyl-4-piperidyl bis (p-chlorophenoxy) acetate (Sandox 42-348) on steroid and drug metabolism by rat liver microsomes.氯贝丁酯和1-甲基-4-哌啶基双（对氯苯氧基）乙酸酯（Sandox 42-348）对大鼠肝脏微粒体甾体和药物代谢的影响。
Life Sci. 1970 Apr 8;9(7):397-407. doi: 10.1016/0024-3205(70)90242-0.
9
Assay of liver microsomal cholesterol 7 alpha-hydroxylase using deuterated carrier and gas chromatography-mass spectrometry.使用氘代载体和气相色谱-质谱联用技术测定肝脏微粒体胆固醇7α-羟化酶
Anal Biochem. 1974 Jun;59(2):508-16. doi: 10.1016/0003-2697(74)90304-2.
10
A biochemical abnormality in cerebrotendinous xanthomatosis. Impairment of bile acid biosynthesis associated with incomplete degradation of the cholesterol side chain.脑腱黄瘤病中的一种生化异常。胆汁酸生物合成受损，与胆固醇侧链不完全降解相关。
J Clin Invest. 1974 May;53(5):1393-401. doi: 10.1172/JCI107688.

氯贝丁酯对大鼠肝脏中参与胆汁酸形成和代谢的某些微粒体羟化作用的影响。

Effects of clofibrate on some microsomal hydroxylations involved in the formation and metabolism of bile acids in rat liver.

作者信息

Angelin B O, Björkhem I, Einarsson K

出版信息

Biochem J. 1976 May 15;156(2):445-8. doi: 10.1042/bj1560445.

DOI:10.1042/bj1560445
PMID:942417
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1163766/
Abstract
  1. The liver microsomal metabolism of [4-14C]cholesterol, endogenous cholesterol, 7 alpha-hydroxy-4-[6 beta-3H]cholesten-3-one, 5-beta-[7 beta-3H]cholestane-3 alpha, 7 alpha-diol and [3H]lithocholic acid was studdied in control and clofibrate (ethyl p-chlorophenoxyisobutyrate)-treated rats. 2. The extent of 7 alpha-hydroxylation of exogenous [414C]cholesterol and endogenous cholesterol, the latter determined with a mass fragmentographic technique, was the same in the two groups of rats. The extent of 12 alpha-hydroxylation of 7 alpha-hydroxy-4-cholesten-3-one and 5 beta-cholestane-3 alpha, 7 alpha-diol was increased by about 60 and 120% respectively by clofibrate treatment. The 26-hydroxylation of 5 beta-cholestane-3 alpha, 7 alpha-diol was not significantly affected by clofibrate. The 6 beta-hydroxylation of lithocholic acid was about 80% higher in the clofibrate-treated animals than in the controls. 3. The results are discussed in the context of present knowledge about the liver microsomal hydroxylating system and bile acid formation in patients with hypercholesterolaemia, treated with clofibrate.
摘要
  1. 在对照大鼠和用氯贝丁酯（对氯苯氧异丁酸乙酯）处理的大鼠中，研究了[4-¹⁴C]胆固醇、内源性胆固醇、7α-羟基-4-[6β-³H]胆甾烯-3-酮、5-β-[7β-³H]胆甾烷-3α,7α-二醇和[³H]石胆酸的肝微粒体代谢。2. 外源性[4¹⁴C]胆固醇和内源性胆固醇（后者用质量碎片图谱技术测定）的7α-羟基化程度在两组大鼠中相同。氯贝丁酯处理使7α-羟基-4-胆甾烯-3-酮和5β-胆甾烷-3α,7α-二醇的12α-羟基化程度分别增加了约60%和120%。氯贝丁酯对5β-胆甾烷-3α,7α-二醇的26-羟基化没有显著影响。在氯贝丁酯处理的动物中，石胆酸的6β-羟基化比对照组高约80%。3. 结合目前关于高胆固醇血症患者肝微粒体羟化系统和胆汁酸形成的知识，对这些结果进行了讨论，这些患者接受了氯贝丁酯治疗。