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Effect of clofibrate and 1-methyl-4-piperidyl bis (p-chlorophenoxy) acetate (Sandox 42-348) on steroid and drug metabolism by rat liver microsomes.

作者信息

Salvador R A, Haber S, Atkins C, Gommi B W, Welch R M

出版信息

Life Sci. 1970 Apr 8;9(7):397-407. doi: 10.1016/0024-3205(70)90242-0.

DOI:10.1016/0024-3205(70)90242-0
PMID:5445848
Abstract
摘要

相似文献

1
Effect of clofibrate and 1-methyl-4-piperidyl bis (p-chlorophenoxy) acetate (Sandox 42-348) on steroid and drug metabolism by rat liver microsomes.氯贝丁酯和1-甲基-4-哌啶基双（对氯苯氧基）乙酸酯（Sandox 42-348）对大鼠肝脏微粒体甾体和药物代谢的影响。
Life Sci. 1970 Apr 8;9(7):397-407. doi: 10.1016/0024-3205(70)90242-0.
2
Laboratory studies of 1-methyl-4-piperidyl bis(p-chlorophenoxy) acetate (SaH 42-348)--a new hypolipidemic agent.新型降血脂药1-甲基-4-哌啶基双（对氯苯氧基）乙酸酯（SaH 42 - 348）的实验室研究
Biochem Pharmacol. 1969 Aug;18(8):1861-71. doi: 10.1016/0006-2952(69)90281-0.
3
Effect of clofibrate on plasma lipids of rat and rabbit.氯贝丁酯对大鼠和家兔血脂的影响。
Atherosclerosis. 1970 May-Jun;11(3):373-82. doi: 10.1016/0021-9150(70)90017-1.
4
The role of cytochrome P-450 and P-448 in drug and steroid hydroxylations.
Ann N Y Acad Sci. 1973;212:156-74. doi: 10.1111/j.1749-6632.1973.tb47594.x.
5
Regulation of hepatic cholesterol biosynthesis by clofibrate administration.氯贝丁酯给药对肝脏胆固醇生物合成的调节作用。
J Pharmacol Exp Ther. 1971 Aug;178(2):361-70.
6
Proliferation of microbodies and synthesis of catalase in rat liver. Induction in tumor-bearing host by CPIB.大鼠肝脏中微体的增殖及过氧化氢酶的合成。CPIB对荷瘤宿主的诱导作用。
Am J Pathol. 1971 Apr;63(1):99-108.
7
Hypocholesterolemic effect of 4,4'-(isopropylidenedithio)-bis(2,6-di-t-butylphenol) (probucol).
Am J Clin Nutr. 1970 Sep;23(9):1229-33. doi: 10.1093/ajcn/23.9.1229.
8
Effect of clofibrate (ethyl-chlorophenoxyisobutyrate) feeding on glycolytic and lipogenic enzymes and hepatic glycogen synthesis in the rat.氯贝丁酯（乙基氯苯氧异丁酸酯）喂养对大鼠糖酵解酶、脂肪生成酶及肝糖原合成的影响。
Biochem Pharmacol. 1970 Jan;19(1):305-10. doi: 10.1016/0006-2952(70)90351-5.
9
Effect of clofibrate administration on the esterification and deesterification of steroid hormones by liver and extrahepatic tissues in rats.氯贝丁酯给药对大鼠肝脏和肝外组织中甾体激素酯化和脱酯作用的影响。
Biochem Pharmacol. 2002 Mar 1;63(5):985-92. doi: 10.1016/s0006-2952(01)00921-2.
10
The effect of hypolipidemic agents on the hepatic microsomal drug-metabolizing enzyme system of the rat. Induction of cytochrome(s) P-450 with specificity toward terminal hydroxylation of lauric acid.降血脂药物对大鼠肝脏微粒体药物代谢酶系统的影响。对月桂酸末端羟基化具有特异性的细胞色素P-450的诱导作用。
Drug Metab Dispos. 1982 Mar-Apr;10(2):110-5.

引用本文的文献

1
Cytochrome P-450 induction by clofibrate. Purification and properties of a hepatic cytochrome P-450 relatively specific for the 12- and 11-hydroxylation of dodecanoic acid (lauric acid).氯贝丁酯对细胞色素P-450的诱导作用。一种对十二烷酸（月桂酸）12-和11-羟化作用相对特异的肝细胞色素P-450的纯化及性质
Biochem J. 1982 Apr 1;203(1):161-8. doi: 10.1042/bj2030161.
2
Effects of clofibrate on the metabolism of progesterone and oestradiol in rat liver microsomal fraction.氯贝丁酯对大鼠肝微粒体部分中孕酮和雌二醇代谢的影响。
Biochem J. 1973 Nov;136(3):623-8. doi: 10.1042/bj1360623.
3
Biosynthesis of pyrimidine nucleotides and level of cytochrome P-450 in rat liver and kidney after clofibrate administration (an in vivo study).
氯贝丁酯给药后大鼠肝脏和肾脏中嘧啶核苷酸的生物合成及细胞色素P-450水平（一项体内研究）
J Cancer Res Clin Oncol. 1988;114(1):59-63. doi: 10.1007/BF00390486.
4
Effect of clofibrate on cholesterol metabolism in rats treated with polychlorinated biphenyls.氯贝丁酯对多氯联苯处理的大鼠胆固醇代谢的影响。
Lipids. 1986 Feb;21(2):159-63. doi: 10.1007/BF02534439.
5
Structure-function activity of azasterols and nitrogen-containing steroids.氮杂甾醇和含氮甾体的结构-功能活性
Lipids. 1976 Oct;11(10):755-62. doi: 10.1007/BF02533051.
6
Morphometric analysis of the ultrastructural changes in rat liver induced by the peroxisome proliferator SaH 42-348.过氧化物酶体增殖剂SaH 42 - 348诱导的大鼠肝脏超微结构变化的形态计量分析
J Cell Biol. 1976 Dec;71(3):768-80. doi: 10.1083/jcb.71.3.768.
7
Effects of clofibrate on some microsomal hydroxylations involved in the formation and metabolism of bile acids in rat liver.氯贝丁酯对大鼠肝脏中参与胆汁酸形成和代谢的某些微粒体羟化作用的影响。
Biochem J. 1976 May 15;156(2):445-8. doi: 10.1042/bj1560445.