调控分化组织中的细胞增殖：G1期至S期进程负调控因子的遗传分析

Controlling cell proliferation in differentiating tissues: genetic analysis of negative regulators of G1-->S-phase progression.

作者信息

Zavitz K H, Zipursky S L

机构信息

Department of Biological Chemistry, School of Medicine, University of California at Los Angeles 90095, USA.

出版信息

Curr Opin Cell Biol. 1997 Dec;9(6):773-81. doi: 10.1016/s0955-0674(97)80077-4.

DOI:10.1016/s0955-0674(97)80077-4

PMID:9425341

Abstract

Withdrawal from the cell cycle as cells begin to differentiate is accomplished by the downregulation of cyclin-dependent kinase activities in G1 phase. Recent analysis of loss-of-function mutations in flies, worms, and mice has provided insight into the roles of various negative regulators of G1 phase in developing organisms.

摘要

随着细胞开始分化而退出细胞周期是通过G1期细胞周期蛋白依赖性激酶活性的下调来实现的。最近对果蝇、线虫和小鼠功能丧失突变的分析，为G1期各种负调控因子在发育生物体中的作用提供了深入了解。