Wakelin S H, Young E, Kelly S, Turner M
Department of Dermatology, Amersham Hospital, Bucks.
Clin Exp Dermatol. 1997 May;22(3):148-51. doi: 10.1111/j.1365-2230.1997.tb01045.x.
Leukaemia cutis arises from cutaneous infiltration by neoplastic leukocytes or their precursors. Recent evidence suggests that this sign does not necessarily herald a poor prognosis. We describe a 72-year-old woman with B-cell chronic lymphatic leukaemia who developed a papular eruption of her breast at the site of a recent herpetic eruption. Histology and immunostaining showed a dense dermal B-cell infiltrate in keeping with leukaemia cutis. The papules cleared in 6 months without treatment, leaving atrophic scars. The histological features and possible aetiological mechanisms of post-herpetic papular eruptions in chronic lymphatic leukaemia are reviewed.
皮肤白血病由肿瘤性白细胞或其前体细胞浸润皮肤引起。近期证据表明，这一征象不一定预示预后不良。我们描述了一名72岁患B细胞慢性淋巴细胞白血病的女性，她在近期疱疹发作部位的乳房出现丘疹性皮疹。组织学检查和免疫染色显示真皮内有密集的B细胞浸润，符合皮肤白血病表现。这些丘疹未经治疗在6个月内消退，留下萎缩性瘢痕。本文对慢性淋巴细胞白血病中疱疹后丘疹性皮疹的组织学特征及可能的病因机制进行了综述。
