Wakelin S H, Young E, Kelly S, Turner M
Department of Dermatology, Amersham Hospital, Bucks, UK.
Clin Exp Dermatol. 1997 Jan;22(1):37-40. doi: 10.1046/j.1365-2230.1997.1890613.x.
Leukaemia cutis arises due to cutaneous infiltration of neoplastic leukocytes or their precursors. Recent evidence suggests that this sign does not necessarily herald a poor prognosis. We describe a 72-year-old woman with B-cell chronic lymphatic leukaemia (CLL) who developed a papular eruption on her breast at the site of a recent herpetic eruption. Histology and immunostaining showed a dense dermal B-cell infiltrate in keeping with leukaemia cutis. The papules cleared in 6 months without treatment, leaving atrophic scars. The histological features and possible aetiological mechanisms of post-herpetic papular eruptions in CLL are reviewed.
皮肤白血病是由肿瘤性白细胞或其前体细胞浸润皮肤引起的。最近的证据表明，这个体征不一定预示着预后不良。我们描述了一名72岁患有B细胞慢性淋巴细胞白血病（CLL）的女性，她在近期疱疹发作的部位乳房上出现了丘疹性皮疹。组织学和免疫染色显示真皮内有密集的B细胞浸润，符合皮肤白血病表现。这些丘疹未经治疗在6个月内消退，留下萎缩性瘢痕。本文对CLL中疱疹后丘疹性皮疹的组织学特征和可能的病因机制进行了综述。
