James R W, Brulhart-Meynet M C, Lehmann T, Golay A
Clinical Diabetes Unit, Medical Faculty, University Hospital, Geneva, Switzerland.
Int J Obes Relat Metab Disord. 1997 Dec;21(12):1115-20. doi: 10.1038/sj.ijo.0800524.
To examine the relationships between the distribution and composition of subfractions of very low density (VLDL), low density (LDL) and high density (HDL) lipoproteins and central fat deposition as measured by the waist-to-hip ratio (WHR).
Participants (n = 62, 44 women and 18 men; body mass index (BMI) > or = 25.0) were recruited from those consecutively attending the outpatient obesity clinic at the University Hospital, Geneva.
Lipoprotein subfractions were isolated from fasting blood samples by cumulative flotation or density gradient ultracentrifugation. Concentration and composition were analysed as a function of obesity indices.
There were significant correlations between the WHR and the profiles of the three major lipoprotein subclasses. Central obesity was associated with larger VLDL, small, dense LDL and lower levels of HDL-2 independently of other indices of obesity and plasma triglycerides. Central obesity was also significantly and independently associated with compositional anomalies, specifically an increased free cholesterol content of VLDL and LDL.
Central body fat was associated with modifications of an atherogenic nature to lipoprotein distribution and composition. The data are consistent with an impact of body fat distribution on cardiovascular disease (CVD) via the agency of modified lipoprotein metabolism independently of raised triglycerides.
通过腰臀比（WHR）来研究极低密度脂蛋白（VLDL）、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）亚组分的分布及组成与中心性脂肪沉积之间的关系。
研究对象（n = 62，44名女性和18名男性；体重指数（BMI）≥25.0）来自于连续就诊于日内瓦大学医院门诊肥胖诊所的患者。
通过累积漂浮法或密度梯度超速离心法从空腹血样中分离脂蛋白亚组分。根据肥胖指标分析其浓度和组成。
WHR与三种主要脂蛋白亚类的分布情况之间存在显著相关性。中心性肥胖与较大的VLDL、小而密的LDL以及较低水平的HDL-2相关，且独立于其他肥胖指标和血浆甘油三酯。中心性肥胖还与组成异常显著且独立相关，特别是VLDL和LDL中游离胆固醇含量增加。
中心性体脂与脂蛋白分布和组成的致动脉粥样硬化性质改变有关。这些数据与体脂分布通过脂蛋白代谢改变对心血管疾病（CVD）产生影响一致，且独立于甘油三酯升高。
