Woudberg Nicholas J, Lecour Sandrine, Goedecke Julia H
Hatter Institute for Cardiovascular Research in Africa, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Non-Communicable Diseases Research Unit, South African Medical Research Council, Parow Valley, Cape Town, South Africa.
J Obes. 2019 Feb 3;2019:2107178. doi: 10.1155/2019/2107178. eCollection 2019.
Although cross-sectional studies have shown that obesity is associated with lower concentrations of large high-density lipoprotein (HDL) subclasses, it is unknown if changes in HDL subclasses are related to changes in body fat and its distribution over time. We therefore assessed changes in HDL subclass distribution over a 5.5-year free-living follow-up period in 24 black South African women. At baseline and follow-up, body composition and body fat distribution were measured using anthropometry, dual X-ray absorptiometry, and computerized tomography. HDL subclass distribution was quantified using Lipoprint®. Over the 5.5-year follow-up period, body fat (+17.3 ± 4.5 kg, < 0.05) and trunk fat mass (+7.4 ± 1.9%, % fat mass, FM, < 0.05) increased, while leg fat mass (-2.53 ± 0.56%, % FM, < 0.001) and the distribution of large (-6.43 ± 2.12%, < 0.05) HDL subclasses decreased. A percentage decrease in large HDL subclasses was associated with a percentage increase in central fat mass (visceral adipose tissue (VAT) area, < 0.05) and a percentage decrease in peripheral fat mass (leg fat mass). These preliminary findings suggest that a relative redistribution of body fat from the periphery to the abdominal region were associated with a decrease HDL subclass size in black South African women and provide a novel link between body fat distribution and lipidology in this population.
尽管横断面研究表明肥胖与大型高密度脂蛋白（HDL）亚类的浓度较低有关，但尚不清楚HDL亚类的变化是否与体脂及其随时间的分布变化有关。因此，我们评估了24名南非黑人女性在5.5年自由生活随访期内HDL亚类分布的变化。在基线和随访时，使用人体测量学、双能X线吸收法和计算机断层扫描测量身体成分和体脂分布。使用Lipoprint®对HDL亚类分布进行量化。在5.5年的随访期内，体脂（+17.3±4.5kg，P<0.05）和躯干脂肪量（+7.4±1.9%，脂肪量百分比，FM，P<0.05）增加，而腿部脂肪量（-2.53±0.56%，FM百分比，P<0.001）和大型HDL亚类的分布（-6.43±2.12%，P<0.05）减少。大型HDL亚类的百分比下降与中心脂肪量（内脏脂肪组织（VAT）面积，P<0.05）的百分比增加和外周脂肪量（腿部脂肪量）的百分比下降有关。这些初步发现表明，南非黑人女性体内脂肪从外周向腹部区域的相对重新分布与HDL亚类大小的减少有关，并在该人群中提供了体脂分布与脂质学之间的新联系。
