小鼠早期营养不良与大脑及行为的产后变化

Early malnutrition and postnatal changes in brain and behavior in the mouse.

作者信息

Castellano C, Oliverio A

出版信息

Brain Res. 1976 Jan 16;101(2):317-25. doi: 10.1016/0006-8993(76)90272-9.

Abstract

The effects of early undernutrition were studied by rearing mice in small, intermediate or large litters (respectively 4, 8 or 16 pups). Measures of reflexes and electrocorticographic activity applied from birth to weaning indicated that malnutrition resulted in a clear ontogenetic retardation which was followed by permanent body and brain stunting. The mice from the large litters were characterized by increased exploratory activity and by lower avoidance learning ability as measured 45 days after nutritional rehabilitation.

摘要

通过将小鼠饲养在小、中、大不同规模的窝中（分别为4只、8只或16只幼崽）来研究早期营养不良的影响。从出生到断奶期间进行的反射和脑电图活动测量表明，营养不良导致明显的个体发育迟缓，随后出现永久性的身体和脑部发育迟缓。营养恢复45天后测量发现，来自大窝的小鼠具有探索活动增加和回避学习能力较低的特点。