Lennox G, Lowe J S, Godwin-Austen R B, Landon M, Mayer R J
Department of Neurology, Queen's Medical Centre, Nottingham, U.K.
Prog Clin Biol Res. 1989;317:121-30.
Fifteen cases of diffuse Lewy body disease were identified in a systematic survey of all 216 brains referred to this hospital from a single health district in a single year. These cases presented with Parkinson's disease (40%), cognitive impairment (40%) and both (20%). Quantitative neuropathological studies using anti-ubiquitin immunocytochemistry revealed that dementia severity was related to cortical Lewy body density. The prevalence of diffuse Lewy body disease may have been underestimated in the past because of the neuropathological difficulties in making the diagnosis. Firstly, cortical Lewy bodies have a subtle appearance and are easy to overlook. Secondly, senile plaques are a common feature of diffuse Lewy body disease and may lead the unwary to make an erroneous diagnosis of Alzheimer's disease or "plaque-only Alzheimer's disease'. Diffuse Lewy body disease is a common and important cause of parkinsonian dementia, including the dementia of Parkinson's disease itself.
在对某一健康区同一年转诊至本院的216例脑标本进行的系统调查中，共识别出15例弥漫性路易体病。这些病例中，40%表现为帕金森病，40%表现为认知障碍，20%两者均有。使用抗泛素免疫细胞化学进行的定量神经病理学研究表明，痴呆严重程度与皮质路易体密度有关。过去，弥漫性路易体病的患病率可能被低估了，原因在于诊断时存在神经病理学方面的困难。其一，皮质路易体外观不明显，容易被忽视。其二，老年斑是弥漫性路易体病的常见特征，可能会使粗心者错误地诊断为阿尔茨海默病或“仅有老年斑的阿尔茨海默病”。弥漫性路易体病是帕金森病性痴呆（包括帕金森病本身所致痴呆）的常见且重要病因。
