Georgala S, Schulpis K H, Potouridou I, Papadogeorgaki H
University Dermatological Clinic, A. Sygros Hospital, Athens, Greece.
Int J Dermatol. 1997 Nov;36(11):863-4. doi: 10.1046/j.1365-4362.1997.00306.x.
Increases in plasma concentrations of lipids, triglycerides, and liver enzymes have been reported in patients on isotretinoin therapy. Lipoprotein (a). (Lp (a)), a cholesterol-rich plasma lipoprotein, influences the clotting system and is related to premature coronary heart disease and stroke.
Blood (7 mL) was obtained from 30 patients with cystic acne before and 30 days after the initiation of oral isotretinoin (0.5 mg/kg/day).
An increase in liver enzymes and lipids, except high density lipoprotein, was found in our patients at the end of the study. The mean Lp (a) levels (initial value, 25.91 +/- 3.17 mg/dL) were statistically reduced (p < 0.0001) at the end of treatment (14.80 +/- 2.35 mg/dL).
It is suggested that isotretinoin could be used as an Lp (a) lowering agent in the future.
据报道，接受异维A酸治疗的患者血浆中脂质、甘油三酯和肝酶浓度会升高。脂蛋白(a) [Lp(a)]是一种富含胆固醇的血浆脂蛋白，会影响凝血系统，与早发性冠心病和中风有关。
从30例囊性痤疮患者开始口服异维A酸（0.5mg/kg/天）前及用药30天后采集血液（7mL）。
在研究结束时，我们的患者中发现肝酶和脂质升高，但高密度脂蛋白除外。治疗结束时，平均Lp(a)水平（初始值为25.91±3.17mg/dL）有统计学意义的降低（p<0.0001）（14.80±2.35mg/dL）。
提示异维A酸未来可作为降低Lp(a)的药物使用。
