全氟辛烷用于玻璃体视网膜手术止血的实验研究。
Experimental studies with perfluoro-octane for hemostasis during vitreoretinal surgery.
作者信息
Moreira Júnior C A, Uscocovich C E, Moreira A T
机构信息
Department of Ophthalmology, Universidade Federal do Parana, Curitiba, Brazil.
出版信息
Retina. 1997;17(6):530-4. doi: 10.1097/00006982-199711000-00007.
PURPOSE
To investigate the effect of perfluoro-octane on coagulation studies and on intraoperative hemostasis during vitreoretinal surgery in an animal model.
METHODS
In vitro study--comparison of coagulation profiles (bleeding time, whole blood clotting time, partial thromboplastin time, and one-stage prothrombin time) of blood taken from healthy volunteers with and without the addition of perfluoro-octane. In vivo study--comparison of times taken to achieve hemostasis in a rabbit model with large retinal arterial bleeding in vitrectomized and aphakic eyes with and without intraocular injection of perfluoro-octane.
RESULTS
In vitro study--perfluoro-octane had no significant effect on coagulation profiles. In vivo study--intraocular perfluoro-octane significantly reduced the time to achieve hemostasis (P < 0.01) at all infusion bottle heights in vitrectomized and aphakic rabbit eyes.
CONCLUSIONS
Perfluoro-octane may be used to control bleeding during vitreoretinal surgery. A direct effect on the clotting cascade could not be demonstrated.
目的
在动物模型中研究全氟辛烷对玻璃体视网膜手术中凝血研究及术中止血的影响。
方法
体外研究——比较添加和不添加全氟辛烷情况下，从健康志愿者采集血液的凝血指标（出血时间、全血凝固时间、部分凝血活酶时间和一步法凝血酶原时间）。体内研究——比较在玻璃体切除且无晶状体的兔眼中，有和没有眼内注射全氟辛烷时，大视网膜动脉出血达到止血所需的时间。
结果
体外研究——全氟辛烷对凝血指标无显著影响。体内研究——在玻璃体切除且无晶状体的兔眼中，眼内注射全氟辛烷在所有输液瓶高度下均显著缩短了达到止血的时间（P < 0.01）。
结论
全氟辛烷可用于控制玻璃体视网膜手术中的出血。未证实其对凝血级联反应有直接作用。
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