Rackow H, Salanitre E
Anesth Analg. 1976 Jan-Feb;55(1):51-6. doi: 10.1213/00000539-197601000-00013.
An in-vitro experiment demonstrated the concentration effect of N2O (3% versus 75%) during elimination and during uptake. Other pulmonary absorption-excretion phenomena also occur simultaneously, as paired events during uptake and then during elimination:diffusion hyperoxia and diffusion anoxia; alveolar concentration of CO2, and alveolar dilution of CO2. These clinical phenomena, as well as the second gas effect, are all related, and the pulmonary absorption-excretion volume is found to depend in part on the type of ventilation:volume controlled, pressure controlled, or spontaneous respiration.
一项体外实验证明了笑气在消除期和摄取期的浓度效应（3% 与 75%）。其他肺吸收 - 排泄现象也同时发生，在摄取期和随后的消除期表现为成对出现的事件：弥散性高氧和弥散性缺氧；二氧化碳的肺泡浓度以及二氧化碳的肺泡稀释。这些临床现象以及第二气体效应都是相关的，并且发现肺吸收 - 排泄量部分取决于通气类型：容量控制通气、压力控制通气或自主呼吸。
