Iscovich J, Shushan A, Schenker J G, Paltiel O
Department of Epidemiology, Israel Cancer Registry, Ministry of Health, Jerusalem.
Cancer. 1998 Jan 1;82(1):147-51. doi: 10.1002/(sici)1097-0142(19980101)82:1<147::aid-cncr18>3.0.co;2-2.
In hospital-based studies, one-eighth of ovarian cancers have been considered borderline ovarian tumors (BOTs). Population-based data regarding the incidence of BOTs are lacking in the international literature. The authors' objectives were to measure the incidence of BOT in Israel and compare rates among ethnic groups (based on ethnic group and country of birth) for the years 1985-1993.
The authors analyzed data reported to a nationwide cancer registry. Population estimates by subpopulation were derived from census and intercensus estimates, which were based on an updated population registry.
The age-adjusted standard rate (ASR) for the entire population was 10.6 per million (95% confidence interval [CI], 9.2-12.0) for the period 1985-1993. Significant differences in ASR were observed among ethnic subgroups, with the lowest incidence among non-Jews (ASR, 5.0 per million; 95% CI, 0.7-9.3) and the highest among new immigrants from the former Soviet Union (FSU) who had been arriving since 1989 (ASR, 22.7 per million; 95% CI: 14.2-31.3). Between the periods 1985-1989 and 1990-1993, the ASR for Jews nearly doubled (rate ratio, 1.86; 95% CI, 1.1-2.5). This near-doubling was influenced, but not wholly accounted for, by the immigration from FSU and was observed in all ethnic subgroups.
The variations in the incidence rates of BOT among ethnic groups may be related to differences in fertility patterns, use of fertility drugs, and genetic predisposition. The pattern of near-doubling in rates may reflect biases caused by increased detection or shifts in the classification of ovarian tumors; if they are real, a biologic explanation is needed.
在基于医院的研究中，八分之一的卵巢癌被认为是交界性卵巢肿瘤（BOT）。国际文献中缺乏基于人群的BOT发病率数据。作者的目的是测量以色列BOT的发病率，并比较1985 - 1993年各民族群体（基于种族和出生国家）之间的发病率。
作者分析了向全国癌症登记处报告的数据。亚人群的人口估计数来自基于更新的人口登记处的人口普查和两次人口普查之间的估计数。
1985 - 1993年期间，整个人口的年龄调整标准率（ASR）为每百万10.6例（95%置信区间[CI]，9.2 - 12.0）。在不同种族亚组中观察到ASR存在显著差异，非犹太人的发病率最低（ASR，每百万5.0例；95% CI，0.7 - 9.3），1989年以来来自前苏联（FSU）的新移民发病率最高（ASR，每百万22.7例；95% CI：14.2 - 31.3）。在1985 - 1989年和1990 - 1993年期间，犹太人的ASR几乎翻了一番（率比，1.86；95% CI，1.1 - 2.5）。这种近乎翻倍的情况受到来自FSU移民的影响，但并未完全由其解释，并且在所有种族亚组中都有观察到。
各民族群体中BOT发病率的差异可能与生育模式、生育药物使用和遗传易感性的差异有关。发病率近乎翻倍的模式可能反映了检测增加或卵巢肿瘤分类变化导致的偏差；如果这些差异是真实的，则需要生物学解释。
