Srugo I, Shinar E, Bar-Shany S, Amos L
Department of Clinical Microbiology, Bnai Zion Medical Center, The Bruce Rappaport Faculty of Medicine, Haifa, Israel.
Eur J Epidemiol. 1998 Jun;14(4):333-7. doi: 10.1023/a:1007409607526.
Patients with alcoholic liver disease have an increased prevalence of viral hepatitis. However, the role of demographic characteristics has not been adequately delineated. Therefore, we examined and compared the seroprevalences of hepatitis B and C in Israeli alcoholic patients to that of blood donors control group by their country of birth and origin. Hepatitis B surface antigen, hepatitis B core antibody and hepatitis C virus antibody testing (second generation ELISA) and a confirmatory recombinant immunoblot assay was performed on 496 alcoholic attending an alcoholic abstinence program and compared to 193,806 randomly non-alcoholic blood donors on the basis of their country of birth. Three hundred twenty-eight alcoholic patients (66%) were immigrants and Israeli born Jews and 168 (34%) were Israeli Arabs. Of the 496 alcoholic patients, 24 (4.8%) were HBsAg positive, 38 (7.6%) were anti HCV positive, and 2 (North African Jews) were positive for both markers. HBsAg was detected in 13 (3.9%) immigrant and Israeli Jews and 11 (6.5%) Israeli Arabs, significantly higher than in the adjusted non alcoholic blood donors (p < 0.01). Anti-HCV was detected in 33 (10%) immigrants and Israeli Jews and 5 (2.9%) Israeli Arabs, significantly higher than in the control group (p < 0.005). In the subgroup alcoholic Jews there was no significant difference in hepatitis B seropositivity among alcoholic that were native Israeli, Eastern Europe and former USSR, and Western Europe and American immigrants comparing to the control group. In contrast, anti-HCV recombinant immunoblot assay seropositivity in alcoholic Jews from all subgroups was significantly greater than in non alcoholic blood donors (p < 0.001). Odds analysis of all ethnic groups revealed that alcoholism requiring detoxification have a significant risk factor for hepatitis C more than hepatitis B (p < 0.001). The increased seroprevalence of hepatitis C among Israeli alcoholic patients, regardless their country of birth and origin, suggest that alcoholism is likely to have a predisposing factor for HCV infection.
酒精性肝病患者中病毒性肝炎的患病率增加。然而，人口统计学特征的作用尚未得到充分描述。因此，我们根据出生国家和原籍，对以色列酒精性肝病患者与献血者对照组的乙肝和丙肝血清流行率进行了检测和比较。对496名参加戒酒项目的酒精性肝病患者进行了乙肝表面抗原、乙肝核心抗体和丙肝病毒抗体检测（第二代酶联免疫吸附测定）以及确认性重组免疫印迹试验，并将其与193,806名随机抽取的非酒精性献血者按出生国家进行比较。328名酒精性肝病患者（66%）是移民和在以色列出生的犹太人，168名（34%）是以色列阿拉伯人。在496名酒精性肝病患者中，24名（4.8%）乙肝表面抗原呈阳性，38名（7.6%）丙肝抗体呈阳性，2名（北非犹太人）两种标志物均呈阳性。在13名（3.9%）移民和以色列犹太人以及11名（6.5%）以色列阿拉伯人中检测到乙肝表面抗原，显著高于经调整的非酒精性献血者（p<0.01）。在33名（10%）移民和以色列犹太人以及5名（2.9%）以色列阿拉伯人中检测到丙肝抗体，显著高于对照组（p<0.005）。在酒精性肝病犹太人群体中，与对照组相比，在以色列本土、东欧和前苏联以及西欧和美国的移民酒精性肝病患者中，乙肝血清阳性率没有显著差异。相比之下，所有亚组的酒精性肝病犹太患者中丙肝重组免疫印迹试验血清阳性率显著高于非酒精性献血者（p<0.001）。对所有种族群体的优势分析显示，需要解毒的酗酒是丙肝比乙肝更显著的危险因素（p<0.001）。以色列酒精性肝病患者中丙肝血清流行率的增加，无论其出生国家和原籍如何，表明酗酒可能是丙肝感染的一个易感因素。
