Méndez A, Pérez J, Ruiz-Villamor E, García R, Martín M P, Mozos E
Departamento de Anatomía y Anatomía Patológica Comparadas, Facultad de Veterinaria, Universidad de Córdoba, Spain.
Vet Rec. 1997 Dec 6;141(23):597-600.
This paper describes the clinical and histopathological features of an outbreak of cutaneous squamous cell carcinomas in a flock of Berrichon du Cher sheep in south-western Spain. The outbreak was unusual because of the high prevalence recorded (15 to 18 per cent over the last two years) and because the majority of the lesions involved the eyelids. Adult and old sheep were the most commonly affected, and the largest numbers of cases were recorded in summer and autumn. The initial lesions were non-specific and consisted of erythema, hyperkeratosis, actinic keratosis, periocular dermatitis and conjunctivitis. The tumours grew slowly but progressively over a period of one to two years, with frequent complications by bacterial infections or secondary myiasis. Histopathological examination of the tumours revealed well-differentiated squamous cell carcinomas, surrounded by a moderate to abundant infiltrate of lymphocytes, plasma cells and macrophages. The overlying epidermis was frequently ulcerated and inflamed. The possible relationships between the high prevalence of the condition and the poorly pigmented skin of this breed, the extensive farming system employed and the exposure of the animals to ultraviolet radiation were analysed.
本文描述了西班牙西南部一群贝里洪·杜·谢尔绵羊中皮肤鳞状细胞癌暴发的临床和组织病理学特征。此次暴发不同寻常，因为记录到的患病率很高（过去两年中为15%至18%），且大多数病变累及眼睑。成年羊和老龄羊最常受到影响，夏季和秋季记录到的病例数量最多。最初的病变是非特异性的，包括红斑、角化过度、光化性角化病、眼周皮炎和结膜炎。肿瘤在一到两年的时间里生长缓慢但呈进行性发展，常伴有细菌感染或继发性蝇蛆病等并发症。对肿瘤的组织病理学检查显示为高分化鳞状细胞癌，周围有中度至大量的淋巴细胞、浆细胞和巨噬细胞浸润。上方的表皮经常发生溃疡和炎症。分析了该病高患病率与该品种皮肤色素沉着不良、所采用的粗放养殖系统以及动物暴露于紫外线辐射之间可能存在的关系。
