Lucey J V, Burness C E, Costa D C, Gacinovic S, Pilowsky L S, Ell P J, Marks I M, Kerwin R W
St Bartholomew's, London, UK.
Br J Med Psychol. 1997 Dec;70(4):403-11. doi: 10.1111/j.2044-8341.1997.tb01916.x.
We compared Wisconsin Card Sorting Task (WCST) performance in 19 obsessive-compulsive disorder (OCD) patients and 19 individually matched healthy controls. Measures of intelligence and mood were taken into account for all participants. Within the patient group, factors such as duration and severity of symptoms (as assessed using the Yale-Brown Obsessive-Compulsive Scale, Y-BOCS) were considered. We explored the relationship between OCD WCST errors and regional cerebral blood flow (rCBF) on brain dedicated, high resolution, single photon emission tomography (SPET). We used uptake of 99mTc-hexamethylpropylamine oxime (HMPAO) on SPET to estimate rCBF, and regional values were quantified as ratios of cerebellar blood flow. WCST results confirmed OCD patients were significantly impared when compared with age- and sex-matched healthy volunteers. Patients made significantly more trials, more preseverative errors, and more null-sorts. OCD patients Y-BOCS 'obsessive' subtotal significantly correlated with many WCST errors. Furthermore OCD WCST null-sorts correlated significantly with SPET OCD left inferior frontal cortical rCBF (r(18) = .47, p = .05) and left caudate rCBF (r(18) = .72, p = .01). The implications of these findings are discussed in the context of other studies which examine functional imaging and neuropsychology in OCD.
我们比较了19名强迫症（OCD）患者和19名个体匹配的健康对照者在威斯康星卡片分类任务（WCST）中的表现。所有参与者均考虑了智力和情绪测量指标。在患者组中，还考虑了症状持续时间和严重程度等因素（使用耶鲁-布朗强迫症量表，Y-BOCS进行评估）。我们利用脑专用的高分辨率单光子发射断层扫描（SPET），探究了强迫症患者WCST错误与局部脑血流量（rCBF）之间的关系。我们在SPET上使用99mTc-六甲基丙烯胺肟（HMPAO）摄取量来估计rCBF，并将局部值量化为小脑血流量的比率。WCST结果证实，与年龄和性别匹配的健康志愿者相比，强迫症患者明显受损。患者进行的试验显著更多，出现的持续性错误和无效分类显著更多。强迫症患者的Y-BOCS“强迫观念”总分与许多WCST错误显著相关。此外，强迫症患者的WCST无效分类与SPET上强迫症患者左前额叶皮质下rCBF显著相关（r(18) = .47，p = .05）以及与左尾状核rCBF显著相关（r(18) = .72，p = .01）。在其他研究强迫症功能成像和神经心理学的背景下，对这些发现的意义进行了讨论。
